Molecola del Mese
di David S. Goodsell
Trad. di Mauro Tonellato
Fibrina

Indice 2006

Structure ID  Title Authors Publication Year Journal Name Volume ID First Page Pubmed
1CEA Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. Mathews, I.I., Vanderhoff-Hanaver, P., Castellino, F.J., Tulinsky, A. 1996 Biochemistry 35 2567 8611560
1CEB Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. Mathews, I.I., Vanderhoff-Hanaver, P., Castellino, F.J., Tulinsky, A. 1996 Biochemistry 35 2567 8611560
1EI3 Crystal structure of native chicken fibrinogen at 5.5-A resolution. Yang, Z., Mochalkin, I., Veerapandian, L., Riley, M., Doolittle, R.F. 2000 Proc.Natl.Acad.Sci.USA 97 3907 10737772
1FBR Solution structure of a pair of fibronectin type 1 modules with fibrin binding activity. Williams, M.J., Phan, I., Harvey, T.S., Rostagno, A., Gold, L.I., Campbell, I.D. 1994 J.Mol.Biol. 235 1302 8308892
1FZA Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. Spraggon, G., Everse, S.J., Doolittle, R.F. 1997 Nature 389 455 9333233
1FZB Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. Spraggon, G., Everse, S.J., Doolittle, R.F. 1997 Nature 389 455 9333233
1FZC Crystal structure of fragment double-D from human fibrin with two different bound ligands. Everse, S.J., Spraggon, G., Veerapandian, L., Riley, M., Doolittle, R.F. 1998 Biochemistry 37 8637 9628725
1FZE Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide. Everse, S.J., Spraggon, G., Veerapandian, L., Doolittle, R.F. 1999 Biochemistry 38 2941 10074346
1FZF Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide. Everse, S.J., Spraggon, G., Veerapandian, L., Doolittle, R.F. 1999 Biochemistry 38 2941 10074346
1FZG Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide. Everse, S.J., Spraggon, G., Veerapandian, L., Doolittle, R.F. 1999 Biochemistry 38 2941 10074346
1HPJ Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1. Rejante, M.R., Llinas, M. 1994 Eur.J.Biochem. 221 939 8181476
1HPK Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1. Rejante, M.R., Llinas, M. 1994 Eur.J.Biochem. 221 939 8181476
1LT9 2.8 A Crystal Structures of Recombinant Fibrinogen Fragment D with and without Two Peptide Ligands: GHRP Binding to the "b" Site Disrupts Its Nearby Calcium-binding Site. Kostelansky, M.S., Betts, L., Gorkun, O.V., Lord, S.T. 2002 Biochemistry 41 12124 12356313
1LTJ 2.8 A Crystal Structures of Recombinant Fibrinogen Fragment D with and without Two Peptide Ligands: GHRP Binding to the "b" Site Disrupts Its Nearby Calcium-binding Site. Kostelansky, M.S., Betts, L., Gorkun, O.V., Lord, S.T. 2002 Biochemistry 41 12124 12356313
1M1J Crystal Structure of Native Chicken Fibrinogen at 2.7 A Resolution Yang, Z., Kollman, J.M., Pandi, L., Doolittle, R.F. 2001 Biochemistry 40 12515 11601975
1N73 The Crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface Yang, Z., Pandi, L., Doolittle, R.F. 2002 Biochemistry 41 15610 12501189
1N86 The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Yang, Z., Pandi, L., Doolittle, R.F. 2002 Biochemistry 41 15610 12501189
1N8E The Crystal Structure of Fragment Double-D from Cross-Linked Lamprey Fibrin Reveals Isopeptide Linkages across an Unexpected D-D Interface Yang, Z., Pandi, L., Doolittle, R.F. 2002 Biochemistry 41 15610 12501189
1O9A Pathogenic Bacteria Attach to Human Fibronectin Thr a Tandem Beta-Zipper Schwarz-Linek, U., Werner, J.M., Pickford, A.R., Kim, S.Gurusidda J.H., Pilka, E.S., Briggs, J.A.G., Gough, T.S., Hook, M., Campbell, I.D., Potts, J.R. 2003 Nature 423 177 n/a
1PK4 Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution. Mulichak, A.M., Tulinsky, A., Ravichandran, K.G. 1991 Biochemistry 30 10576 1657148
1PKR The structure of recombinant plasminogen kringle 1 and the fibrin binding site. Wu, T.P., Padmanabhan, K.P., Tulinsky, A. 1994 Blood Coagul.Fibrinolysis 5 157 8054447
1RF0 Calcium-Binding Site beta2, Adjacent to the "b" Polymerization Site, Modulates Lateral Aggregation of Protofibrils during Fibrin Polymerization. Kostelansky, M.S., Lounes, K.C., Ping, L.F., Dickerson, S.K., Gorkun, O.V., Lord, S.T. 2004 Biochemistry 43 2475 14992585
1RF1 Calcium-Binding Site beta2, Adjacent to the "b" Polymerization Site, Modulates Lateral Aggregation of Protofibrils during Fibrin Polymerization. Kostelansky, M.S., Lounes, K.C., Ping, L.F., Dickerson, S.K., Gorkun, O.V., Lord, S.T. 2004 Biochemistry 43 2475 14992585
1RT8 Structure of the actin Crosslinking core of fimbrin Klein, M.G., Shi, W., Ramagopal, U., Tseng, Y., Wirtz, D., Kovar, D.R., Staiger, C.J., Almo, S.C. 2004 Structure 12 999 n/a
1TPM Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance. Downing, A.K., Driscoll, P.C., Harvey, T.S., Dudgeon, T.J., Smith, B.O., Baron, M., Campbell, I.D. 1992 J.Mol.Biol. 225 821 1602484
1TPN Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance. Downing, A.K., Driscoll, P.C., Harvey, T.S., Dudgeon, T.J., Smith, B.O., Baron, M., Campbell, I.D. 1992 J.Mol.Biol. 225 821 1602484
1VZQ Enantiomerically Pure Thrombin Inhibitors for Exploring the Molecular-Recognition Features of the Oxyanion Hole Schaerer, K., Morgenthaler, M., Seiler, P., Diederich, F., Banner, D.W., Tschopp, T., Obst-Sander, U. 2004 Helv.Chim.Acta 87 2517 n/a
1W7G Thrombin Inhibitors Designed for Grafting on Biomaterials. Salvagnini, C., Michaux, C., Remiche, J., Wouters, J., Charlier, P., Marchand-Brynaert, J. 2005 Org.Biomol.Chem. 3 4209 n/a
1WAY Fragment-Based Lead Discovery Using X-Ray Crystallography Hartshorn, M.J., Murray, C.W., Cleasby, A., Frederickson, M., Tickle, I.J., Jhoti, H. 2005 J.Med.Chem. 48 403 n/a
1WBG Fragment-Based Lead Discovery Using X-Ray Crystallography Hartshorn, M.J., Murray, C.W., Cleasby, A., Frederickson, M., Tickle, I.J., Jhoti, H. 2005 J.Med.Chem. 48 403 n/a
1YP1 Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus Lou, Z., Hou, J., Liang, X., Chen, J., Qiu, P., Liu, Y., Li, M., Rao, Z., Yan, G. 2005 J.Struct.Biol. 152 195 16330227
2A45 Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly. Pechik, I., Yakovlev, S., Mosesson, M.W., Gilliland, G.L., Medved, L. 2006 Biochemistry 45 3588 16533041
2BAF Identification of an Ordered Compact Structure within the Recombinant Bovine Fibrinogen alphaC-Domain Fragment by NMR. Burton, R.A., Tsurupa, G., Medved, L., Tjandra, N. 2006 Biochemistry 45 2257 16475814
2C8W Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors Howard, N., Abell, C., Blakemore, W., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C.A., Van Montfort, R.L.M. 2006 J.Med.Chem. 49 1346 n/a
2C8X Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors Howard, N., Abell, C., Blakemore, W., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C.A., Van Montfort, R.L.M. 2006 J.Med.Chem. 49 1346 n/a
2C8Y Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors Howard, N., Abell, C., Blakemore, W., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C.A., Van Montfort, R.L.M. 2006 J.Med.Chem. 49 1346 n/a
2C8Z Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors Howard, N., Abell, C., Blakemore, W., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C.A., Van Montfort, R.L.M. 2006 J.Med.Chem. 49 1346 n/a
2C90 Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors Howard, N., Abell, C., Blakemore, W., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C.A., Van Montfort, R.L.M. 2006 J.Med.Chem. 49 1346 n/a
2C93 Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors Howard, N., Abell, C., Blakemore, W., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C.A., Van Montfort, R.L.M. 2006 J.Med.Chem. 49 1346 n/a
2CF8 Multipolar Interactions in the D Pocket of Thrombin: Large Differences between Tricyclic Imide and Lactam Inhibitors. Schweizer, E., Hoffmann-Roeder, A., Olsen, J.A., Seiler, P., Obst-Sander, U., Wagner, B., Kansy, M., Banner, D.W., Diederich, F. 2006 Org.Biomol.Chem. 4 2364 n/a
2CF9 Multipolar Interactions in the D Pocket of Thrombin: Large Differences between Tricyclic Imide and Lactam Inhibitors. Schweizer, E., Hoffmann-Roeder, A., Olsen, J.A., Seiler, P., Obst-Sander, U., Wagner, B., Kansy, M., Banner, D.W., Diederich, F. 2006 Org.Biomol.Chem. 4 2364 n/a
2FIB The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. Pratt, K.P., Cote, H.C., Chung, D.W., Stenkamp, R.E., Davie, E.W. 1997 Proc.Natl.Acad.Sci.USA 94 7176 9207064
2PK4 The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4. Wu, T.P., Padmanabhan, K., Tulinsky, A., Mulichak, A.M. 1991 Biochemistry 30 10589 1657149
3FIB The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. Pratt, K.P., Cote, H.C., Chung, D.W., Stenkamp, R.E., Davie, E.W. 1997 Proc.Natl.Acad.Sci.USA 94 7176 9207064

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