Molecola del Mese
di David S. Goodsell
Trad. di Mauro Tonellato
Citocromo p450

Indice 2006

Structure ID  Title Authors Publication Year Journal Name Volume ID First Page Pubmed
1AKD Crystal structure of cytochrome P-450cam
complexed with the (1S)-camphor enantiomer. 		Schlichting, I., Jung, C., Schulze, H. 1997 FEBS Lett. 415 253 9357977
1AMO Three-dimensional structure of NADPH-cytochrome
P450 reductase: prototype for FMN- and FAD-containing
enzymes. 		Wang, M., Roberts, D.L., Paschke, R., Shea,
T.M., Masters, B.S., Kim, J.J. 		1997 Proc.Natl.Acad.Sci.USA 94 8411 9237990
1B1C Crystal structure of the FMN-binding domain
of human cytochrome P450 reductase at 1.93
A resolution. 		Zhao, Q., Modi, S., Smith, G., Paine, M.,
McDonagh, P.D., Wolf, C.R., Tew, D., Lian,
L.Y., Roberts, G.C., Driessen, H.P. 		1999 Protein Sci. 8 298 10048323
1BU7 Structure of a cytochrome P450-redox partner
electron-transfer complex. 		Sevrioukova, I.F., Li, H., Zhang, H., Peterson,
J.A., Poulos, T.L. 		1999 Proc.Natl.Acad.Sci.USA 96 1863 10051560
1BVY Structure of a cytochrome P450-redox partner
electron-transfer complex. 		Sevrioukova, I.F., Li, H., Zhang, H., Peterson,
J.A., Poulos, T.L. 		1999 Proc.Natl.Acad.Sci.USA 96 1863 10051560
1CL6 Proton delivery in NO reduction by fungal
nitric-oxide reductase. Cryogenic crystallography,
spectroscopy, and kinetics of ferric-NO
complexes of wild-type and mutant enzymes. 		Shimizu, H., Obayashi, E., Gomi, Y., Arakawa,
H., Park, S.Y., Nakamura, H., Adachi, S.,
Shoun, H., Shiro, Y. 		2000 J.Biol.Chem. 275 4816 10671516
1CMJ Proton delivery in NO reduction by fungal
nitric-oxide reductase. Cryogenic crystallography,
spectroscopy, and kinetics of ferric-NO
complexes of wild-type and mutant enzymes. 		Shimizu, H., Obayashi, E., Gomi, Y., Arakawa,
H., Park, S.Y., Nakamura, H., Adachi, S.,
Shoun, H., Shiro, Y. 		2000 J.Biol.Chem. 275 4816 10671516
1CMN Proton delivery in NO reduction by fungal
nitric-oxide reductase. Cryogenic crystallography,
spectroscopy, and kinetics of ferric-NO
complexes of wild-type and mutant enzymes. 		Shimizu, H., Obayashi, E., Gomi, Y., Arakawa,
H., Park, S.Y., Nakamura, H., Adachi, S.,
Shoun, H., Shiro, Y. 		2000 J.Biol.Chem. 275 4816 10671516
1CP4 Formation, crystal structure, and rearrangement
of a cytochrome P-450cam iron-phenyl complex. 		Raag, R., Swanson, B.A., Poulos, T.L., Ortiz
de Montellano, P.R. 		1990 Biochemistry 29 8119 2261467
1CPO The crystal structure of chloroperoxidase:
a heme peroxidase--cytochrome P450 functional
hybrid. 		Sundaramoorthy, M., Terner, J., Poulos, T.L. 1995 Structure 3 1367 8747463
1CPT Crystal structure and refinement of cytochrome
P450terp at 2.3 A resolution. 		Hasemann, C.A., Ravichandran, K.G., Peterson,
J.A., Deisenhofer, J. 		1994 J.Mol.Biol. 236 1169 8120894
1DDG Four crystal structures of the 60 kDa flavoprotein
monomer of the sulfite reductase indicate
a disordered flavodoxin-like module. 		Gruez, A., Pignol, D., Zeghouf, M., Coves,
J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps,
J.C. 		2000 J.Mol.Biol. 299 199 10860732
1DDI Four crystal structures of the 60 kDa flavoprotein
monomer of the sulfite reductase indicate
a disordered flavodoxin-like module. 		Gruez, A., Pignol, D., Zeghouf, M., Coves,
J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps,
J.C. 		2000 J.Mol.Biol. 299 199 10860732
1DT6 Mammalian microsomal cytochrome P450 monooxygenase:
structural adaptations for membrane binding
and functional diversity. 		Williams, P.A., Cosme, J., Sridhar, V., Johnson,
E.F., McRee, D.E. 		2000 Mol.Cell 5 121 10678174
1DZ4 The catalytic pathway of cytochrome p450cam
at atomic resolution. 		Schlichting, I., Berendzen, J., Chu, K.,
Stock, A.M., Maves, S.A., Benson, D.E.,
Sweet, R.M., Ringe, D., Petsko, G.A., Sligar,
S.G. 		2000 Science 287 1615 10698731
1DZ6 The catalytic pathway of cytochrome p450cam
at atomic resolution. 		Schlichting, I., Berendzen, J., Chu, K.,
Stock, A.M., Maves, S.A., Benson, D.E.,
Sweet, R.M., Ringe, D., Petsko, G.A., Sligar,
S.G. 		2000 Science 287 1615 10698731
1DZ8 The catalytic pathway of cytochrome p450cam
at atomic resolution. 		Schlichting, I., Berendzen, J., Chu, K.,
Stock, A.M., Maves, S.A., Benson, D.E.,
Sweet, R.M., Ringe, D., Petsko, G.A., Sligar,
S.G. 		2000 Science 287 1615 10698731
1DZ9 The catalytic pathway of cytochrome p450cam
at atomic resolution. 		Schlichting, I., Berendzen, J., Chu, K.,
Stock, A.M., Maves, S.A., Benson, D.E.,
Sweet, R.M., Ringe, D., Petsko, G.A., Sligar,
S.G. 		2000 Science 287 1615 10698731
1E6E Adrenodoxin reductase-adrenodoxin complex
structure suggests electron transfer path
in steroid biosynthesis. 		Muller, J.J., Lapko, A., Bourenkov, G., Ruckpaul,
K., Heinemann, U. 		2001 J.Biol.Chem. 276 2786 11053423
1E9X Crystal structure of cytochrome P450 14alpha
-sterol demethylase (CYP51) from Mycobacterium
tuberculosis in complex with azole inhibitors 		Podust, L.M., Poulos, T.L., Waterman, M.R. 2001 Proc.Natl.Acad.Sci.USA 98 3068 11248033
1EA1 Crystal structure of cytochrome P450 14alpha
-sterol demethylase (CYP51) from Mycobacterium
tuberculosis in complex with azole inhibitors 		Podust, L.M., Poulos, T.L., Waterman, M.R. 2001 Proc.Natl.Acad.Sci.USA 98 3068 11248033
1EGY Crystal structures of ligand complexes of
P450eryF exhibiting homotropic cooperativity. 		Cupp-Vickery, J., Anderson, R., Hatziris,
Z. 		2000 Proc.Natl.Acad.Sci.USA 97 3050 10716705
1EHE Crystal structures of cytochrome P450nor
and its mutants (Ser286-->Val, Thr) in the
ferric resting state at cryogenic temperature:
a comparative analysis with monooxygenase
cytochrome P450s. 		Shimizu, H., Park, S., Lee, D., Shoun, H.,
Shiro, Y. 		2000 J.Inorg.Biochem. 81 191 11051564
1EHF Crystal structures of cytochrome P450nor
and its mutants (Ser286-->Val, Thr) in the
ferric resting state at cryogenic temperature:
a comparative analysis with monooxygenase
cytochrome P450s. 		Shimizu, H., Park, S., Lee, D., Shoun, H.,
Shiro, Y. 		2000 J.Inorg.Biochem. 81 191 11051564
1EHG Crystal structures of cytochrome P450nor
and its mutants (Ser286-->Val, Thr) in the
ferric resting state at cryogenic temperature:
a comparative analysis with monooxygenase
cytochrome P450s. 		Shimizu, H., Park, S., Lee, D., Shoun, H.,
Shiro, Y. 		2000 J.Inorg.Biochem. 81 191 11051564
1EUP Crystal structures of ligand complexes of
P450eryF exhibiting homotropic cooperativity. 		Cupp-Vickery, J., Anderson, R., Hatziris,
Z. 		2000 Proc.Natl.Acad.Sci.USA 97 3050 10716705
1F20 Crystal structure of the FAD/NADPH-binding
domain of rat neuronal nitric-oxide synthase.
Comparisons with NADPH-cytochrome P450 oxidoreductase. 		Zhang, J., Martasek, P., Paschke, R., Shea,
T., Siler Masters, B.S., Kim, J.J. 		2001 J.Biol.Chem. 276 37506 11473123
1F24 Mutation Effects of Conserved Threonine(Thr243)
of Cytochrome P450nor on Its Structure and
Function 		Shimizu, H., PARK, S.-Y. n/a To be Published n/a n/a n/a
1F25 Mutation Effects of Conserved Threonine(Thr243)
of Cytochrome P450nor on Its Structure and
Function 		Shimizu, H., PARK, S.-Y. n/a To be Published n/a n/a n/a
1F26 Mutation Effects of Conserved Threonine(Thr243)
of Cytochrome P450nor on Its Structure and
Function 		Shimizu, H., PARK, S.-Y. n/a To be Published n/a n/a n/a
1F4T Crystal structure of a thermophilic cytochrome
P450 from the archaeon Sulfolobus solfataricus. 		Yano, J.K., Koo, L.S., Schuller, D.J., Li,
H., Ortiz de Montellano, P.R., Poulos, T.L. 		2000 J.Biol.Chem. 275 31086 10859321
1F4U Crystal structure of a thermophilic cytochrome
P450 from the archaeon Sulfolobus solfataricus. 		Yano, J.K., Koo, L.S., Schuller, D.J., Li,
H., Ortiz de Montellano, P.R., Poulos, T.L. 		2000 J.Biol.Chem. 275 31086 10859321
1FAG The structure of the cytochrome p450BM-3
haem domain complexed with the fatty acid
substrate, palmitoleic acid. 		Li, H., Poulos, T.L. 1997 Nat.Struct.Biol. 4 140 9033595
1FAH The role of Thr268 in oxygen activation of
cytochrome P450BM-3. 		Yeom, H., Sligar, S.G., Li, H., Poulos, T.L.,
Fulco, A.J. 		1995 Biochemistry 34 14733 7578081
1GED A positively charged cluster formed in the
heme-distal pocket of cytochrome P450nor
is essential for interaction with NADH 		Kudo, T., Takaya, N., Park, S.-Y., Shiro,
Y., Shoun, H. 		2001 J.Biol.Chem. 276 5020 11076941
1GEI Structural characterization of n-butyl-isocyanide
complexes of cytochromes P450nor and P450cam. 		Lee, D.S., Park, S.Y., Yamane, K., Obayashi,
E., Hori, H., Shiro, Y. 		2001 Biochemistry 40 2669 11258878
1GEJ Structural characterization of n-butyl-isocyanide
complexes of cytochromes P450nor and P450cam. 		Lee, D.S., Park, S.Y., Yamane, K., Obayashi,
E., Hori, H., Shiro, Y. 		2001 Biochemistry 40 2669 11258878
1GEK Structural characterization of n-butyl-isocyanide
complexes of cytochromes P450nor and P450cam. 		Lee, D.S., Park, S.Y., Yamane, K., Obayashi,
E., Hori, H., Shiro, Y. 		2001 Biochemistry 40 2669 11258878
1GEM Structural characterization of n-butyl-isocyanide
complexes of cytochromes P450nor and P450cam. 		Lee, D.S., Park, S.Y., Yamane, K., Obayashi,
E., Hori, H., Shiro, Y. 		2001 Biochemistry 40 2669 11258878
1GJM Covalent Attachment of an Electroactive Sulphydryl
Reagent in the Active Site of Cytochrome
P450Cam as Revealed by the Crystal Structure
of the Modified Protein 		Digleria, K., Nickerson, D.P., Hill, H.A.O.,
Wong, L.-L., Fulop, V. 		1998 J.Am.Chem.Soc. 120 46 n/a
1GWI The 1.92 A Structure of Streptomyces Coelicolor
A3(2) Cyp154C1: A New Monooxygenase that
Functionalizes Macrolide Ring Systems 		Podust, L., Kim, Y., Arase, M., Neely, B.,
Beck, B., Bach, H., Sherman, D., Lamb, D.,
Kelly, S., Waterman, M. 		2003 J.Biol.Chem. 278 12214 n/a
1H5Z Estriol Bound and Ligand-Free Structures
of Sterol 14Alpha-Demethylase 		Podust, L.M., Yermalitskaya, L.V., Lepesheva,
G.I., Dalmasso, V.N.Podu E.A., Waterman,
M.R. 		2004 Structure 12 1937 n/a
1IO7 Crystallization and preliminary X-ray diffraction
analysis of a cytochrome P450 (CYP119) from
Sulfolobus solfataricus. 		Park, S.Y., Yamane, K., Adachi, S., Shiro,
Y., Weiss, K.E., Sligar, S.G. 		2000 Acta Crystallogr., Sect.D 56 1173 10957637
1IO8 Crystallization and preliminary X-ray diffraction
analysis of a cytochrome P450 (CYP119) from
Sulfolobus solfataricus. 		Park, S.Y., Yamane, K., Adachi, S., Shiro,
Y., Weiss, K.E., Sligar, S.G. 		2000 Acta Crystallogr., Sect.D 56 1173 10957637
1IO9 Crystallization and preliminary X-ray diffraction
analysis of a cytochrome P450 (CYP119) from
Sulfolobus solfataricus. 		Park, S.Y., Yamane, K., Adachi, S., Shiro,
Y., Weiss, K.E., Sligar, S.G. 		2000 Acta Crystallogr., Sect.D 56 1173 10957637
1IZO Substrate Recognition and Molecular Mechanism
of Fatty Acid Hydroxylation by Cytochrome
P450 from Bacillus subtilis. CRYSTALLOGRAPHIC,
SPECTROSCOPIC, AND MUTATIONAL STUDIES. 		Lee, D.S., Yamada, A., Sugimoto, H., Matsunaga,
I., Ogura, H., Ichihara, K., Adachi, S.,
Park, S.Y., Shiro, Y. 		2003 J.Biol.Chem. 278 9761 12519760
1J9Z NADPH-cytochrome P450 oxidoreductase. Structural
basis for hydride and electron transfer. 		Hubbard, P.A., Shen, A.L., Paschke, R., Kasper,
C.B., Kim, J.J. 		2001 J.Biol.Chem. 276 29163 11371558
1JA0 NADPH-cytochrome P450 oxidoreductase. Structural
basis for hydride and electron transfer. 		Hubbard, P.A., Shen, A.L., Paschke, R., Kasper,
C.B., Kim, J.J. 		2001 J.Biol.Chem. 276 29163 11371558
1JA1 NADPH-cytochrome P450 oxidoreductase. Structural
basis for hydride and electron transfer. 		Hubbard, P.A., Shen, A.L., Paschke, R., Kasper,
C.B., Kim, J.J. 		2001 J.Biol.Chem. 276 29163 11371558
1JFB X-ray structure of nitric oxide reductase
(cytochrome P450nor) at atomic resolution 		Shimizu, H., Park, S.Y., Shiro, Y., Adachi,
S. 		2002 Acta Crystallogr., Sect.D 58 81 11752781
1JFC X-ray structure of nitric oxide reductase
(cytochrome P450nor) at atomic resolution 		Shimizu, H., Park, S.Y., Shiro, Y., Adachi,
S. 		2002 Acta Crystallogr., Sect.D 58 81 11752781
1JIN Ketoconazole-induced conformational changes
in the active site of cytochrome P450eryF. 		Cupp-Vickery, J.R., Garcia, C., Hofacre,
A., McGee-Estrada, K. 		2001 J.Mol.Biol. 311 101 11469860
1JIO Ketoconazole-induced conformational changes
in the active site of cytochrome P450eryF. 		Cupp-Vickery, J.R., Garcia, C., Hofacre,
A., McGee-Estrada, K. 		2001 J.Mol.Biol. 311 101 11469860
1JIP Ketoconazole-induced conformational changes
in the active site of cytochrome P450eryF. 		Cupp-Vickery, J.R., Garcia, C., Hofacre,
A., McGee-Estrada, K. 		2001 J.Mol.Biol. 311 101 11469860
1JME Structural and spectroscopic analysis of
the F393H mutant of flavocytochrome P450
BM3. 		Ost, T.W., Munro, A.W., Mowat, C.G., Taylor,
P.R., Pesseguiero, A., Fulco, A.J., Cho,
A.K., Cheesman, M.A., Walkinshaw, M.D.,
Chapman, S.K. 		2001 Biochemistry 40 13430 11695889
1JPZ Pivotal role of water in the mechanism of
P450BM-3. 		Haines, D.C., Tomchick, D.R., Machius, M.,
Peterson, J.A. 		2001 Biochemistry 40 13456 11695892
1K2O Probing the open state of cytochrome P450cam
with ruthenium-linker substrates. 		Dunn, A.R., Dmochowski, I.J., Bilwes, A.M.,
Gray, H.B., Crane, B.R. 		2001 Proc.Natl.Acad.Sci.USA 98 12420 11606730
1LFK Crystal Structure of OxyB, a Cytochrome P450
Implicated in an Oxidative Phenol Coupling
Reaction during Vancomycin Biosynthesis. 		Zerbe, K., Pylypenko, O., Vitali, F., Zhang,
W., Rouset, S., Heck, M., Vrijbloed, J.W.,
Bischoff, D., Bister, B., Sussmuth, R.D.,
Pelzer, S., Wohlleben, W., Robinson, J.A.,
Schlichting, I. 		2002 J.Biol.Chem. 277 47476 12207020
1LG9 Crystal Structure of OxyB, a Cytochrome P450
Implicated in an Oxidative Phenol Coupling
Reaction during Vancomycin Biosynthesis. 		Zerbe, K., Pylypenko, O., Vitali, F., Zhang,
W., Rouset, S., Heck, M., Vrijbloed, J.W.,
Bischoff, D., Bister, B., Sussmuth, R.D.,
Pelzer, S., Wohlleben, W., Robinson, J.A.,
Schlichting, I. 		2002 J.Biol.Chem. 277 47476 12207020
1LGF Crystal Structure of OxyB, a Cytochrome P450
Implicated in an Oxidative Phenol Coupling
Reaction during Vancomycin Biosynthesis. 		Zerbe, K., Pylypenko, O., Vitali, F., Zhang,
W., Rouset, S., Heck, M., Vrijbloed, J.W.,
Bischoff, D., Bister, B., Sussmuth, R.D.,
Pelzer, S., Wohlleben, W., Robinson, J.A.,
Schlichting, I. 		2002 J.Biol.Chem. 277 47476 12207020
1LWL Fluorescent probes for cytochrome P450 structural
characterization and inhibitor screening 		Dunn, A.R., Hays, A.M., Goodin, D.B., Stout,
C.D., Chiu, R., Winkler, J.R., Gray, H.B. 		2002 J.AM.CHEM.SOC. 124 10254 12197708
1N40 Atomic structure of Mycobacterium tuberculosis
CYP121 to 1.06 A reveals novel features
of cytochrome P450. 		Leys, D., Mowat, C.G., McLean, K.J., Richmond,
A., Chapman, S.K., Walkinshaw, M.D., Munro,
A.W. 		2003 J.Biol.Chem. 278 5141 12435731
1N4G Atomic structure of Mycobacterium tuberculosis
CYP121 to 1.06 A reveals novel features
of cytochrome P450. 		Leys, D., Mowat, C.G., McLean, K.J., Richmond,
A., Chapman, S.K., Walkinshaw, M.D., Munro,
A.W. 		2003 J.Biol.Chem. 278 5141 12435731
1N6B Structure of a Substrate Complex of Mammalian
Cytochrome P450 2C5 at 2.3 A Resolution:
Evidence for Multiple Substrate Binding
Modes 		Wester, M.R., Johnson, E.F., Marques-Soares,
C., Dansette, P.M., Mansuy, D., Stout, C.D. 		2003 Biochemistry 42 6370 12767218
1N97 Preliminary Characterization and Crystal
Structure of a Thermostable Cytochrome P450
from Thermus thermophilus 		Yano, J.K., Blasco, F., Li, H., Schmid, R.D.,
Henne, A., Poulos, T.L. 		2003 J.Biol.Chem. 278 608 12401810
1NR6 Structure of Mammalian Cytochrome P450 2C5
Complexed with Diclofenac at 2.1 A Resolution:
Evidence for an Induced Fit Model of Substrate
Binding 		WESTER, M.R., JOHNSON, E.F., Marques-Soares,
C., Dijols, S., Dansette, P.M., Mansuy,
D., STOUT, C.D. 		2003 Biochemistry 42 9335 12899620
1O76 Crystal Structures of Cyanide Complexes of
P450Cam and the Oxygenase Domain of Inducible
Nitric Oxide Synthase-Structural Models
of the Short-Lived Oxygen Complexes 		Fedorov, R., Ghosh, D., Schlichting, I. 2003 Arch.Biochem.Biophys. 409 25 n/a
1ODO Comparison of the 1.85 A Structure of Cyp154A1
from Streptomyces Coelicolor A3(2) with
the Closely Related Cyp154C1 and Cyps from
Antibiotic Biosynthetic Pathways 		Podust, L.M., Bach, H., Kim, Y., Lamb, D.C.,
Arase, M., Kelly, D.H.Sherma S.L., Waterman,
M.R. 		2004 Protein Sci. 13 255 n/a
1OG2 Crystal Structure of Human Cytochrome P450
2C9 with Bound Warfarin 		Williams, P.A., Cosme, J., Ward, A., Angove,
H.C., Matak Vinkovic, D., Jhoti, H. 		2003 Nature 424 464 n/a
1OG5 Crystal Structure of Human Cytochrome P450
2C9 with Bound Warfarin 		Williams, P.A., Cosme, J., Ward, A., Angove,
H.C., Matak Vinkovic, D., Jhoti, H. 		2003 Nature 424 464 n/a
1OXA Structure of cytochrome P450eryF involved
in erythromycin biosynthesis. 		Cupp-Vickery, J.R., Poulos, T.L. 1995 Nat.Struct.Biol. 2 144 7749919
1P0V Oxygen Activation and Electron Transfer in
Flavocytochrome P450 BM3 		Ost, T.W.B., Clark, J., Mowat, C.G., Miles,
C.S., Walkinshaw, M.D., Reid, G.A., Chapman,
S.K., Daff, S. 		2003 J.Am.Chem.Soc. 125 15010 14653735
1P0W Oxygen Activation and Electron Transfer in
Flavocytochrome P450 BM3 		Ost, T.W.B., Clark, J., Mowat, C.G., Miles,
C.S., Walkinshaw, M.D., Reid, G.A., Chapman,
S.K., Daff, S. 		2003 J.Am.Chem.Soc. 125 15010 14653735
1P0X Oxygen Activation and Electron Transfer in
Flavocytochrome P450 BM3 		Ost, T.W.B., Clark, J., Mowat, C.G., Miles,
C.S., Walkinshaw, M.D., Reid, G.A., Chapman,
S.K., Daff, S. 		2003 J.Am.Chem.Soc. 125 15010 14653735
1PHA Inhibitor-induced conformational change in
cytochrome P-450CAM. 		Raag, R., Li, H., Jones, B.C., Poulos, T.L. 1993 Biochemistry 32 4571 8485133
1PHB Inhibitor-induced conformational change in
cytochrome P-450CAM. 		Raag, R., Li, H., Jones, B.C., Poulos, T.L. 1993 Biochemistry 32 4571 8485133
1PHC Crystal structure of substrate-free Pseudomonas
putida cytochrome P-450. 		Poulos, T.L., Finzel, B.C., Howard, A.J. 1986 Biochemistry 25 5314 3768350
1PHD Crystal structures of metyrapone- and phenylimidazole-inhibited
complexes of cytochrome P-450cam. 		Poulos, T.L., Howard, A.J. 1987 Biochemistry 26 8165 3442650
1PHE Crystal structures of metyrapone- and phenylimidazole-inhibited
complexes of cytochrome P-450cam. 		Poulos, T.L., Howard, A.J. 1987 Biochemistry 26 8165 3442650
1PHF Crystal structures of metyrapone- and phenylimidazole-inhibited
complexes of cytochrome P-450cam. 		Poulos, T.L., Howard, A.J. 1987 Biochemistry 26 8165 3442650
1PHG Crystal structures of metyrapone- and phenylimidazole-inhibited
complexes of cytochrome P-450cam. 		Poulos, T.L., Howard, A.J. 1987 Biochemistry 26 8165 3442650
1PO5 An open conformation of mammalian cytochrome
P450 2B4 at 1.6 A resolution 		Scott, E.E., He, Y.A., Wester, M.R., White,
M.A., Chin, C.C., Halpert, J.R., Johnson,
E.F., Stout, C.D. 		2003 Proc.Natl.Acad.Sci.USA 100 13196 14563924
1PQ2 Structure of human microsomal cytochrome
P450 2C8. Evidence for a peripheral fatty
acid binding site 		Schoch, G.A., Yano, J.K., Wester, M.R., Griffin,
K.J., Stout, C.D., Johnson, E.F. 		2004 J.Biol.Chem. 279 9497 14676196
1Q5D Crystal structures of epothilone D-bound,
epothilone B-bound, and substrate-free forms
of cytochrome P450epoK 		Nagano, S., Li, H., Shimizu, H., Nishida,
C., Ogura, H., Ortiz de Montellano, P.R.,
Poulos, T.L. 		2003 J.Biol.Chem. 278 44886 12933799
1Q5E Crystal structures of epothilone D-bound,
epothilone B-bound, and substrate-free forms
of cytochrome P450epoK 		Nagano, S., Li, H., Shimizu, H., Nishida,
C., Ogura, H., Ortiz de Montellano, P.R.,
Poulos, T.L. 		2003 J.Biol.Chem. 278 44886 12933799
1QMQ Optical detection of cytochrome P450 by sensitizer-linked
substrates. 		Dmochowski, I.J., Crane, B.R., Wilker, J.J.,
Winkler, J.R., Gray, H.B. 		1999 Proc.Natl.Acad.Sci.USA 96 12987 10557259
1R9O The Structure of Human Cytochrome P450 2C9
Complexed with Flurbiprofen at 2.0 A Resolution 		Wester, M.R., Yano, J.K., Schoch, G.A., Yang,
C., Griffin, K.J., Stout, C.D., Johnson,
E.F. 		2004 J.Biol.Chem. 279 35630 15181000
1ROM Crystal structure of nitric oxide reductase
from denitrifying fungus Fusarium oxysporum. 		Park, S.Y., Shimizu, H., Adachi, S., Nakagawa,
A., Tanaka, I., Nakahara, K., Shoun, H.,
Obayashi, E., Nakamura, H., Iizuka, T.,
Shiro, Y. 		1997 Nat.Struct.Biol. 4 827 9334748
1S1F Binding of Two Flaviolin Substrate Molecules,
Oxidative Coupling, and Crystal Structure
of Streptomyces coelicolor A3(2) Cytochrome
P450 158A2 		Zhao, B., Guengerich, F.P., Bellamine, A.,
Lamb, D.C., Izumikawa, M., Lei, L., Podust,
L.M., Sundaramoorthy, M., Kalaitzis, J.A.,
Reddy, L.M., Kelly, S.L., Moore, B.S., Stec,
D., Voehler, M., Falck, J.R., Shimada, T.,
Waterman, M.R. 		2005 J.Biol.Chem. 280 11599 15659395
1SE6 Binding of Two Flaviolin Substrate Molecules,
Oxidative Coupling, and Crystal Structure
of Streptomyces coelicolor A3(2) Cytochrome
P450 158A2. 		Zhao, B., Guengerich, F.P., Bellamine, A.,
Lamb, D.C., Izumikawa, M., Lei, L., Podust,
L.M., Sundaramoorthy, M., Kalaitzis, J.A.,
Reddy, L.M., Kelly, S.L., Moore, B.S., Stec,
D., Voehler, M., Falck, J.R., Shimada, T.,
Waterman, M.R. 		2005 J.Biol.Chem. 280 11599 15659395
1SMI A Single Mutation in Cytochrome P450 BM3
Induces the Conformational Rearrangement
Seen upon Substrate Binding in the Wild-type
Enzyme 		Joyce, M.G., Girvan, H.M., Munro, A.W., Leys,
D. 		2004 J.Biol.Chem. 279 23287 15020590
1SMJ A Single Mutation in Cytochrome P450 BM3
Induces the Conformational Rearrangement
Seen upon Substrate Binding in the Wild-type
Enzyme 		Joyce, M.G., Girvan, H.M., Munro, A.W., Leys,
D. 		2004 J.Biol.Chem. 279 23287 15020590
1SUO Structure of mammalian cytochrome P450 2B4
complexed with 4-(4-chlorophenyl)imidazole
at 1.9 {angstrom} resolution: Insight into
the range of P450 conformations and coordination
of redox partner binding. 		Scott, E.E., White, M.A., He, Y.A., Johnson,
E.F., Stout, C.D., Halpert, J.R. 		2004 J.Biol.Chem. 279 27294 15100217
1T85 Crystal structure of the cytochrome p450cam
mutant that exhibits the same spectral perturbations
induced by putidaredoxin binding 		Nagano, S., Tosha, T., Ishimori, K., Morishima,
I., Poulos, T.L. 		2004 J.Biol.Chem. 279 42844 15269210
1T86 Crystal structure of the cytochrome p450cam
mutant that exhibits the same spectral perturbations
induced by putidaredoxin binding 		Nagano, S., Tosha, T., Ishimori, K., Morishima,
I., Poulos, T.L. 		2004 J.Biol.Chem. 279 42844 15269210
1T87 Crystal structure of the cytochrome p450cam
mutant that exhibits the same spectral perturbations
induced by putidaredoxin binding 		Nagano, S., Tosha, T., Ishimori, K., Morishima,
I., Poulos, T.L. 		2004 J.Biol.Chem. 279 42844 15269210
1T88 Crystal structure of the cytochrome p450cam
mutant that exhibits the same spectral perturbations
induced by putidaredoxin binding 		Nagano, S., Tosha, T., Ishimori, K., Morishima,
I., Poulos, T.L. 		2004 J.Biol.Chem. 279 42844 15269210
1T93 Binding of Two Flaviolin Substrate Molecules,
Oxidative Coupling, and Crystal Structure
of Streptomyces coelicolor A3(2) Cytochrome
P450 158A2. 		Zhao, B., Guengerich, F.P., Bellamine, A.,
Lamb, D.C., Izumikawa, M., Lei, L., Podust,
L.M., Sundaramoorthy, M., Kalaitzis, J.A.,
Reddy, L.M., Kelly, S.L., Moore, B.S., Stec,
D., Voehler, M., Falck, J.R., Shimada, T.,
Waterman, M.R. 		2005 J.Biol.Chem. 280 11599 15659395
1TQN The Structure of Human Microsomal Cytochrome
P450 3A4 Determined by X-ray Crystallography
to 2.05-A Resolution 		Yano, J.K., Wester, M.R., Schoch, G.A., Griffin,
K.J., Stout, C.D., Johnson, E.F. 		2004 J.Biol.Chem. 279 38091 15258162
1U13 Crystal structure analysis of the C37L/C151T/C442A-triple
mutant of CYP51 from Mycobacterium tuberculosis 		Podust, L.M., Yermalitskaya, L.V., Kim, Y.,
Waterman, M.R. 		n/a To be published n/a n/a n/a
1UE8 Structure and direct electrochemistry of
cytochrome P450 from the thermoacidophilic
crenarchaeon, Sulfolobus tokodaii strain
7 		Oku, Y., Ohtaki, A., Kamitori, S., Nakamura,
N., Yohda, M., Ohno, H., Kawarabayasi, Y. 		2004 J.Inorg.Biochem. 98 1194 15219985
1UED Crystal structure of OxyC, a cytochrome P450
implicated in an oxidative C-C coupling
reaction during vancomycin biosynthesis 		Pylypenko, O., Vitali, F., Zerbe, K., Robinson,
J.A., Schlichting, I. 		2003 J.Biol.Chem. 278 46727 12888556
1ULW Structural evidence for direct hydride transfer
from NADH to cytochrome P450nor 		Oshima, R., Fushinobu, S., Su, F., Zhang,
L., Takaya, N., Shoun, H. 		2004 J.Mol.Biol. 342 207 15313618
1UYU A Survey of Active Site Access Channels in
Cytochromes P450 		Wade, R.C., Winn, P.J., Schlichting, I.,
Sudarko 		2004 J.Inorg.Biochem. 98 1175 n/a
1W0E Crystal Structures of Human Cytochrome P450
3A4 Bound to Metyrapone and Progesterone 		Williams, P.A., Cosme, J., Vinkovic, D.M.,
Ward, A., Angove, H.C., Day, P.J., Vonrhein,
C., Tickle, I.J., Jhoti, H. 		2004 Science 305 683 n/a
1W0F Crystal Structures of Human Cytochrome P450
3A4 Bound to Metyrapone and Progesterone 		Williams, P.A., Cosme, J., Vinkovic, D.M.,
Ward, A., Angove, H.C., Day, P.J., Vonrhein,
C., Tickle, I.J., Jhoti, H. 		2004 Science 305 683 n/a
1W0G Crystal Structures of Human Cytochrome P450
3A4 Bound to Metyrapone and Progesterone 		Williams, P.A., Cosme, J., Vinkovic, D.M.,
Ward, A., Angove, H.C., Day, P.J., Vonrhein,
C., Tickle, I.J., Jhoti, H. 		2004 Science 305 683 n/a
1WIY Crystal Structure Analysis of Cytochrome
P450 from Thermus thermophilus HB8 		Kousumi, Y., Nakagawa, N., Kaneko, M., Yamamoto,
H., Masui, R., Kuramitsu, S., Ueyama, N. 		n/a To be Published n/a n/a n/a
1X8V Estriol Bound and Ligand-free Structures
of Sterol 14alpha-Demethylase. 		Podust, L.M., Yermalitskaya, L.V., Lepesheva,
G.I., Podust, V.N., Dalmasso, E.A., Waterman,
M.R. 		2004 Structure 12 1937 15530358
1XQD Structural evidence for direct hydride transfer
from NADH to cytochrome P450nor 		Oshima, R., Fushinobu, S., Su, F., Zhang,
L., Takaya, N., Shoun, H. 		2004 J.Mol.Biol. 342 207 15313618
1YQO The role of Thr268 and Phe393 in cytochrome
P450 BM3. 		Clark, J.P., Miles, C.S., Mowat, C.G., Walkinshaw,
M.D., Reid, G.A., Daff, S.N., Chapman, S.K. 		2006 J.Inorg.Biochem. 100 1075 16403573
1YQP The role of Thr268 and Phe393 in cytochrome
P450 BM3. 		Clark, J.P., Miles, C.S., Mowat, C.G., Walkinshaw,
M.D., Reid, G.A., Daff, S.N., Chapman, S.K. 		2006 J.Inorg.Biochem. 100 1075 16403573
1Z10 Structures of human microsomal cytochrome
P450 2A6 complexed with coumarin and methoxsalen 		Yano, J.K., Hsu, M.H., Griffin, K.J., Stout,
C.D., Johnson, E.F. 		2005 Nat.Struct.Mol.Biol. 12 822 16086027
1Z11 Structures of human microsomal cytochrome
P450 2A6 complexed with coumarin and methoxsalen 		Yano, J.K., Hsu, M.H., Griffin, K.J., Stout,
C.D., Johnson, E.F. 		2005 Nat.Struct.Mol.Biol. 12 822 16086027
1Z8O Crystal Structures of the Ferrous Dioxygen
Complex of Wild-Type Cytochrome P450Eryf
and its Mutants, A245S and A245T: Investigation
of the Proton Transfer System in P450Eryf 		Nagano, S., Cupp-Vickery, J.R., Poulos, T.L. 2005 J.Biol.Chem. 280 22102 15824115
1Z8P Crystal Structures of the Ferrous Dioxygen
Complex of Wild-Type Cytochrome P450Eryf
and its Mutants, A245S and A245T: Investigation
of the Proton Transfer System in P450Eryf 		Poulos, T.L., Nagano, S. 2005 J.Biol.Chem. 280 22102 15824115
1Z8Q Crystal Structures of the Ferrous Dioxygen
Complex of Wild-Type Cytochrome P450Eryf
and its Mutants, A245S and A245T: Investigation
of the Proton Transfer System in P450Eryf 		Nagano, S., Cupp-Vickery, J.R., Poulos, T.L. 2005 J.Biol.Chem. 280 22102 15824115
1ZO4 Active Site Mutations of P450BM-3 that Dramatically
Affect Substrate Binding and Product Formation 		Hegda, A., Chen, B., Haines, D.C., Bondlela,
M., Mullin, D., Graham, S.E., Tomchick,
D.R., Machius, M., Peterson, J.A. 		n/a To be Published n/a n/a n/a
1ZO9 Interactions of Substrates at the Surface
of P450s: A Novel Design for P450 Inhibitors 		Hegda, A., Chen, B., Tomchick, D.R., Bondlela,
M., Haines, D.C., Schaffer, N., Machius,
M., Graham, S.E., Peterson, J.A. 		n/a To be Published n/a n/a n/a
1ZOA Active Site Mutations of P450BM-3 that Dramatically
Affect Substrate Binding and Product Formation 		Hegda, A., Chen, B., Haines, D.C., Bondlela,
M., Mullin, D., Graham, S.E., Tomchick,
D.R., Machius, M., Peterson, J.A. 		n/a To be Published n/a n/a n/a
2A1M Crystallographic study on the dioxygen complex
of wild-type and mutant cytochrome P450cam.
Implications for the dioxygen activation
mechanism 		Nagano, S., Poulos, T.L. 2005 J.Biol.Chem. 280 31659 15994329
2A1N Crystallographic study on the dioxygen complex
of wild-type and mutant cytochrome P450cam.
Implications for the dioxygen activation
mechanism 		Nagano, S., Poulos, T.L. 2005 J.Biol.Chem. 280 31659 15994329
2A1O Crystallographic study on the dioxygen complex
of wild-type and mutant cytochrome P450cam.
Implications for the dioxygen activation
mechanism 		Nagano, S., Poulos, T.L. 2005 J.Biol.Chem. 280 31659 15994329
2BDM Structure of microsomal cytochrome P450 2B4
complexed with the antifungal drug bifonazole:
insight into P450 conformational plasticity
and membrane interaction. 		Zhao, Y., White, M.A., Muralidhara, B.K.,
Sun, L., Halpert, J.R., Stout, C.D. 		2006 J.Biol.Chem. 281 5973 16373351
2BF4 A Second Fmn-Binding Site in Yeast Nadph-Cytochrome
P450 Reductase Suggests a Mechanism of Electron
Transfer by Diflavin Reductases. 		Lamb, D.C., Kim, Y., Yermalitskaya, L.V.,
Yermalitsky, V.N., Lepesheva, G.I., Kelly,
S.L., Waterman, M.R., Podust, L.M. 		2006 Structure 14 51 n/a
2BMH Modeling Protein-Substrate Interactions in
the Heme Domain of Cytochrome P450Bm-3 		Li, H., Poulos, T.L. 1995 Acta Crystallogr.,Sect.D 51 21 n/a
2BN4 A Second Fmn-Binding Site in Yeast Nadph-Cytochrome
P450 Reductase Suggests a Mechanism of Electron
Transfer by Diflavin Reductases. 		Lamb, D.C., Kim, Y., Yermalitskaya, L.V.,
Yermalitsky, V.N., Lepesheva, G.I., Kelly,
S.L., Waterman, M.R., Podust, L.M. 		2006 Structure 14 51 n/a
2BPO Crystal Structure of the Yeast Cpr Triple
Mutant: D74G, Y75F, K78A. 		Yermalitskaya, L.V., Kim, Y., Waterman, M.R.,
Podust, L.M. 		n/a To be Published n/a n/a n/a
2BT6 Light-Induced Reduction of Bovine Adrenodoxin
Via the Covalently Bound Ruthenium(II) Bipyridyl
Complex: Intramolecular Electron Transfer
and Crystal Structure. 		Halavaty, A., Mueller, J.J., Contzen, J.,
Jung, C., Hannemann, F., Bernhardt, R.,
Galander, M., Lendzian, F., Heinemann, U. 		2006 Biochemistry 45 709 n/a
2BVJ The Structural Basis for Substrate Anchoring,
Active Site Selectivity, and Product Formation
by P450 Pikc from Streptomyces Venezuelae. 		Sherman, D.H., Li, S., Yermalitskaya, L.V.,
Kim, Y., Smith, J.A., Waterman, M.R., Podust,
L.M. 		2006 J.Biol.Chem. 281 26289 n/a
2C6H The Structural Basis for Substrate Anchoring,
Active Site Selectivity, and Product Formation
by P450 Pikc from Streptomyces Venezuelae. 		Sherman, D.H., Li, S., Yermalitskaya, L.V.,
Kim, Y., Smith, J.A., Waterman, M.R., Podust,
L.M. 		2006 J.Biol.Chem. 281 26289 n/a
2C7X The Structural Basis for Substrate Anchoring,
Active Site Selectivity, and Product Formation
by P450 Pikc from Streptomyces Venezuelae. 		Sherman, D.H., Li, S., Yermalitskaya, L.V.,
Kim, Y., Smith, J.A., Waterman, M.R., Podust,
L.M. 		2006 J.Biol.Chem. 281 26289 n/a
2CII The Crystal Structure of H-2Db Complexed
with a Partial Peptide Epitope Suggests
a Major Histocompatibility Complex Class
I Assembly Intermediate. 		Glithero, A., Tormo, J., Doering, K., Kojima,
M., Jones, E.Y., Elliott, T. 		2006 J.Biol.Chem. 281 12699 n/a
2CP4 Crystal structure of the cytochrome P-450CAM
active site mutant Thr252Ala. 		Raag, R., Martinis, S.A., Sligar, S.G., Poulos,
T.L. 		1991 Biochemistry 30 11420 1742281
2CPO The crystal structure of chloroperoxidase:
a heme peroxidase--cytochrome P450 functional
hybrid. 		Sundaramoorthy, M., Terner, J., Poulos, T.L. 1995 Structure 3 1367 8747463
2CPP High-resolution crystal structure of cytochrome
P450cam. 		Poulos, T.L., Finzel, B.C., Howard, A.J. 1987 J.Mol.Biol. 195 687 3656428
2D09 Role of active site water molecules and substrate
hydroxyl groups in oxygen activation by
cytochrome P450 158A2: a new mechanism of
proton transfer 		Zhao, B., Guengerich, F.P., Voehler, M.,
Waterman, M.R. 		2005 J.Biol.Chem. 280 42188 16239228
2D0E Role of active site water molecules and substrate
hydroxyl groups in oxygen activation by
cytochrome P450 158A2: a new mechanism of
proton transfer 		Zhao, B., Guengerich, F.P., Voehler, M.,
Waterman, M.R. 		2005 J.Biol.Chem. 280 42188 16239228
2EVK Structures of thiolate- and carboxylate-ligated
ferric H93G myoglobin: models for cytochrome
P450 and for oxyanion-bound heme proteins. 		Qin, J., Perera, R., Lovelace, L.L., Dawson,
J.H., Lebioda, L. 		2006 Biochemistry 45 3170 16519512
2EVP Structures of Thiolate- and Carboxylate-Ligated
Ferric H93G Myoglobin: Models for Cytochrome
P450 and for Oxyanion-Bound Heme Proteins(,). 		Qin, J., Perera, R., Lovelace, L.L., Dawson,
J.H., Lebioda, L. 		2006 Biochemistry 45 3170 16519512
2F9Q Crystal Structure of Human Cytochrome P450
2D6 		Rowland, P., Blaney, F.E., Smyth, M.G., Jones,
J.J., Leydon, V.R., Oxbrow, A.K., Lewis,
C.J., Tennant, M.G., Modi, S., Eggleston,
D.S., Chenery, R.J., Bridges, A.M. 		2006 J.Biol.Chem. 281 7614 16352597
2FE6 The status of high-valent metal oxo complexes
in the P450 cytochromes. 		Makris, T.M., Koenig, K., Schlichting, I.,
Sligar, S.G. 		2006 J.Inorg.Biochem. 100 507 16510191
2FER The status of high-valent metal oxo complexes
in the P450 cytochromes. 		Makris, T.M., von Koenig, K., Schlichting,
I., Sligar, S.G. 		2006 J.Inorg.Biochem. 100 507 16510191
2FEU The status of high-valent metal oxo complexes
in the P450 cytochromes. 		Makris, T.M., von Koenig, K., Schlichting,
I., Sligar, S.G. 		2006 J.Inorg.Biochem. 100 507 16510191
2H6P Alloreactivity between disparate cognate
and allogeneic pMHC-I complexes is resultant
of highly focused, peptide-dependent structural
mimicry 		Archbold, J.K., Macdonald, W.A., Miles, J.J.,
Brennan, R.M., Kjer-Nielsen, L., McCluskey,
J., Burrows, S.R., Rossjohn, J. 		n/a To be Published n/a n/a n/a
2HPD Crystal structure of hemoprotein domain of
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2J0C Structural Basis for Ligand Promiscuity in
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2J0D Structural Basis for Ligand Promiscuity in
Cytochrome P450 3A4 		Ekroos, M., Sjogren, T. 2006 Proc.Natl.Acad.Sci.USA 103 13682 n/a
2ROM Crystal structure of nitric oxide reductase
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A., Tanaka, I., Nakahara, K., Shoun, H.,
Obayashi, E., Nakamura, H., Iizuka, T.,
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32C2 Structure of an activity suppressing Fab
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3CP4 Crystal structure of the cytochrome P-450CAM
active site mutant Thr252Ala. 		Raag, R., Martinis, S.A., Sligar, S.G., Poulos,
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3CPP Crystal structure of the carbon monoxide-substrate-cytochrome
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4CP4 Crystal structure of the cytochrome P-450CAM
active site mutant Thr252Ala. 		Raag, R., Martinis, S.A., Sligar, S.G., Poulos,
T.L. 		1991 Biochemistry 30 11420 1742281
4CPP Crystal structures of cytochrome P-450CAM
complexed with camphane, thiocamphor, and
adamantane: factors controlling P-450 substrate
hydroxylation. 		Raag, R., Poulos, T.L. 1991 Biochemistry 30 2674 2001355
5CP4 Understanding the role of the essential Asp251
in cytochrome p450cam using site-directed
mutagenesis, crystallography, and kinetic
solvent isotope effect. 		Vidakovic, M., Sligar, S.G., Li, H., Poulos,
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5CPP The structural basis for substrate-induced
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6CP4 Understanding the role of the essential Asp251
in cytochrome p450cam using site-directed
mutagenesis, crystallography, and kinetic
solvent isotope effect. 		Vidakovic, M., Sligar, S.G., Li, H., Poulos,
T.L. 		1998 Biochemistry 37 9211 9649301
6CPP Crystal structures of cytochrome P-450CAM
complexed with camphane, thiocamphor, and
adamantane: factors controlling P-450 substrate
hydroxylation. 		Raag, R., Poulos, T.L. 1991 Biochemistry 30 2674 2001355
7CPP The structural basis for substrate-induced
changes in redox potential and spin equilibrium
in cytochrome P-450CAM. 		Raag, R., Poulos, T.L. 1989 Biochemistry 28 917 2713354
8CPP Crystal structures of cytochrome P-450CAM
complexed with camphane, thiocamphor, and
adamantane: factors controlling P-450 substrate
hydroxylation. 		Raag, R., Poulos, T.L. 1991 Biochemistry 30 2674 2001355

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