Molecola del Mese
di David S. Goodsell
Trad. di Mauro Tonellato
Proteina Precursore della
beta-Amiloide

Indice 2006

Structure ID  Title Authors Publication Year Journal Name Volume ID First Page Pubmed
1AAP X-ray crystal structure of the protease inhibitor
domain of Alzheimer's amyloid beta-protein
precursor. 		Hynes, T.R., Randal, M., Kennedy, L.A., Eigenbrot,
C., Kossiakoff, A.A. 		1990 Biochemistry 29 10018 2125487
1AMB Solution structure of residues 1-28 of the
amyloid beta-peptide. 		Talafous, J., Marcinowski, K.J., Klopman,
G., Zagorski, M.G. 		1994 Biochemistry 33 7788 7516706
1AMC Solution structure of residues 1-28 of the
amyloid beta-peptide. 		Talafous, J., Marcinowski, K.J., Klopman,
G., Zagorski, M.G. 		1994 Biochemistry 33 7788 7516706
1AML Structure of amyloid A4-(1-40)-peptide of
Alzheimer's disease. 		Sticht, H., Bayer, P., Willbold, D., Dames,
S., Hilbich, C., Beyreuther, K., Frank,
R.W., Rosch, P. 		1995 Eur.J.Biochem. 233 293 7588758
1AQC Sequence-specific recognition of the internalization
motif of the Alzheimer's amyloid precursor
protein by the X11 PTB domain. 		Zhang, Z., Lee, C.H., Mandiyan, V., Borg,
J.P., Margolis, B., Schlessinger, J., Kuriyan,
J. 		1997 EMBO J. 16 6141 9321393
1BA4 Solution structure of amyloid beta-peptide(1-40)
in a water-micelle environment. Is the membrane-spanning
domain where we think it is? 		Coles, M., Bicknell, W., Watson, A.A., Fairlie,
D.P., Craik, D.J. 		1998 Biochemistry 37 11064 9693002
1BA6 Solution structure of methionine-oxidized
amyloid beta-peptide (1-40). Does oxidation
affect conformational switching? 		Watson, A.A., Fairlie, D.P., Craik, D.J. 1998 Biochemistry 37 12700 9737846
1BJB Solution structures in aqueous SDS micelles
of two amyloid beta peptides of A beta(1-28)
mutated at the alpha-secretase cleavage
site (K16E, K16F) 		Poulsen, S.-A., Watson, A.A., Craik, D.J. 2000 J.Struct.Biol. 130 142 10940222
1BJC Solution structures in aqueous SDS micelles
of two amyloid beta peptides of A beta(1-28)
mutated at the alpha-secretase cleavage
site (K16E, K16F) 		Poulsen, S.-A., Watson, A.A., Craik, D.J. 2000 J.Struct.Biol. 130 142 10940222
1BPT Crevice-forming mutants in the rigid core
of bovine pancreatic trypsin inhibitor:
crystal structures of F22A, Y23A, N43G,
and F45A. 		Danishefsky, A.T., Housset, D., Kim, K.S.,
Tao, F., Fuchs, J., Woodward, C., Wlodawer,
A. 		1993 Protein Sci. 2 577 8518731
1BRC Relocating a negative charge in the binding
pocket of trypsin. 		Perona, J.J., Tsu, C.A., McGrath, M.E., Craik,
C.S., Fletterick, R.J. 		1993 J.Mol.Biol. 230 934 8478942
1BTI Crevice-forming mutants in the rigid core
of bovine pancreatic trypsin inhibitor:
crystal structures of F22A, Y23A, N43G,
and F45A. 		Danishefsky, A.T., Housset, D., Kim, K.S.,
Tao, F., Fuchs, J., Woodward, C., Wlodawer,
A. 		1993 Protein Sci. 2 577 8518731
1CA0 Crystal structures of bovine chymotrypsin
and trypsin complexed to the inhibitor domain
of Alzheimer's amyloid beta-protein precursor
(APPI) and basic pancreatic trypsin inhibitor
(BPTI): engineering of inhibitors with altered
specificities. 		Scheidig, A.J., Hynes, T.R., Pelletier, L.A.,
Wells, J.A., Kossiakoff, A.A. 		1997 Protein Sci. 6 1806 9300481
1CBW Crystal structures of bovine chymotrypsin
and trypsin complexed to the inhibitor domain
of Alzheimer's amyloid beta-protein precursor
(APPI) and basic pancreatic trypsin inhibitor
(BPTI): engineering of inhibitors with altered
specificities. 		Scheidig, A.J., Hynes, T.R., Pelletier, L.A.,
Wells, J.A., Kossiakoff, A.A. 		1997 Protein Sci. 6 1806 9300481
1FAN Crevice-forming mutants in the rigid core
of bovine pancreatic trypsin inhibitor:
crystal structures of F22A, Y23A, N43G,
and F45A. 		Danishefsky, A.T., Housset, D., Kim, K.S.,
Tao, F., Fuchs, J., Woodward, C., Wlodawer,
A. 		1993 Protein Sci. 2 577 8518731
1HZ3 The Alzheimer's peptide a beta adopts a collapsed
coil structure in water. 		Zhang, S., Iwata, K., Lachenmann, M.J., Peng,
J.W., Li, S., Stimson, E.R., Lu, Y., Felix,
A.M., Maggio, J.E., Lee, J.P. 		2000 J.Struct.Biol. 130 130 10940221
1MWP Crystal structure of the N-terminal, growth
factor-like domain of Alzheimer amyloid
precursor protein. 		Rossjohn, J., Cappai, R., Feil, S.C., Henry,
A., McKinstry, W.J., Galatis, D., Hesse,
L., Multhaup, G., Beyreuther, K., Masters,
C.L., Parker, M.W. 		1999 Nat.Struct.Biol. 6 327 10201399
1NAG Crevice-forming mutants in the rigid core
of bovine pancreatic trypsin inhibitor:
crystal structures of F22A, Y23A, N43G,
and F45A. 		Danishefsky, A.T., Housset, D., Kim, K.S.,
Tao, F., Fuchs, J., Woodward, C., Wlodawer,
A. 		1993 Protein Sci. 2 577 8518731
1OWT Structure of the Alzheimer's Disease Amyloid
Precursor Protein Copper Binding Domain.
A REGULATOR OF NEURONAL COPPER HOMEOSTASIS. 		Barnham, K.J., McKinstry, W.J., Multhaup,
G., Galatis, D., Morton, C.J., Curtain,
C.C., Williamson, N.A., White, A.R., Hinds,
M.G., Norton, R.S., Beyreuther, K., Masters,
C.L., Parker, M.W., Cappai, R. 		2003 J.Biol.Chem. 278 17401 12611883
1QCM Three-dimensional structures of the amyloid
beta peptide (25-35) in membrane-mimicking
environment. 		Kohno, T., Kobayashi, K., Maeda, T., Sato,
K., Takashima, A. 		1996 Biochemistry 35 16094 8973180
1R4M The structure of the APPBP1-UBA3-NEDD8-ATP
complex reveals the basis for selective
ctivation by an
E1 		Walden, H., Podgorski, M.S., Huang, D.T.,
Miller, D.W., Howard, R.J., Minor Jr., D.L.,
Holton, J.M., Schulman, B.A. 		2003 Mol. Cell 12 1427 n/a
1R4N The structure of the APPBP1-UBA3-NEDD8-ATP
complex reveals the basis for selective
ctivation by an
E1 		Walden, H., Podgorski, M.S., Huang, D.T.,
Miller, D.W., Howard, R.J., Minor Jr., D.L.,
Holton, J.M., Schulman, B.A. 		2003 Mol. Cell 12 1427 n/a
1RW6 The x-ray structure of an antiparallel dimer
of the human amyloid precursor protein e2
domain. 		Wang, Y., Ha, Y. 2004 Mol. Cell 15 343 15304215
1T7C Crystal structures of five bovine chymotrypsin
complexes with P1 BPTI variants. 		Czapinska, H., Helland, R., Smalas, A.O.,
Otlewski, J. 		2004 J.Mol.Biol. 344 1005 15544809
1T8L Crystal structures of five bovine chymotrypsin
complexes with P1 BPTI variants. 		Czapinska, H., Helland, R., Smalas, A.O.,
Otlewski, J. 		2004 J.Mol.Biol. 344 1005 15544809
1T8M Crystal structures of five bovine chymotrypsin
complexes with P1 BPTI variants. 		Czapinska, H., Helland, R., Smalas, A.O.,
Otlewski, J. 		2004 J.Mol.Biol. 344 1005 15544809
1T8N Crystal structures of five bovine chymotrypsin
complexes with P1 BPTI variants. 		Czapinska, H., Helland, R., Smalas, A.O.,
Otlewski, J. 		2004 J.Mol.Biol. 344 1005 15544809
1T8O Crystal structures of five bovine chymotrypsin
complexes with P1 BPTI variants. 		Czapinska, H., Helland, R., Smalas, A.O.,
Otlewski, J. 		2004 J.Mol.Biol. 344 1005 15544809
1TAW Crystal structures of bovine chymotrypsin
and trypsin complexed to the inhibitor domain
of Alzheimer's amyloid beta-protein precursor
(APPI) and basic pancreatic trypsin inhibitor
(BPTI): engineering of inhibitors with altered
specificities. 		Scheidig, A.J., Hynes, T.R., Pelletier, L.A.,
Wells, J.A., Kossiakoff, A.A. 		1997 Protein Sci. 6 1806 9300481
1TKN Three-Dimensional Structure of an Independently
Folded Extracellular Domain of Human Amyloid-beta
Precursor Protein 		Dulubova, I., Ho, A., Huryeva, I., Sudhof,
T.C., Rizo, J. 		2004 Biochemistry 43 9583 n/a
1U37 Autoinhibition of X11/Mint scaffold proteins
revealed by the closed conformation of the
PDZ tandem 		Long, J.-F., Feng, W., Wang, R., Chan, L.-N.,
Ip, F.C., Xia, J., Ip, N.Y., Zhang, M. 		2005 Nat.Struct.Mol.Biol. 12 722 16007100
1U38 Autoinhibition of X11/Mint scaffold proteins
revealed by the closed conformation of the
PDZ tandem 		Long, J.-F., Feng, W., Wang, R., Chan, L.-N.,
Ip, F.C., Xia, J., Ip, N.Y., Zhang, M. 		2005 Nat.Struct.Mol.Biol. 12 722 16007100
1U39 Autoinhibition of X11/Mint scaffold proteins
revealed by the closed conformation of the
PDZ tandem 		Long, J.-F., Feng, W., Wang, R., Chan, L.-N.,
Ip, F.C., Xia, J., Ip, N.Y., Zhang, M. 		2005 Nat.Struct.Mol.Biol. 12 722 16007100
1U3B Autoinhibition of X11/Mint scaffold proteins
revealed by the closed conformation of the
PDZ tandem 		Long, J.-F., Feng, W., Wang, R., Chan, L.-N.,
Ip, F.C., Xia, J., Ip, N.Y., Zhang, M. 		2005 Nat.Struct.Mol.Biol. 12 722 16007100
1WGU Solution Structure of the C-terminal Phosphotyrosine
Interaction Domain of APBB2 from Mouse 		Li, H., Hayashi, F., Koshiba, S., Inoue,
M., Kigawa, T., Yokoyama, S. 		n/a To be Published n/a n/a n/a
1X11 Sequence-specific recognition of the internalization
motif of the Alzheimer's amyloid precursor
protein by the X11 PTB domain. 		Zhang, Z., Lee, C.H., Mandiyan, V., Borg,
J.P., Margolis, B., Schlessinger, J., Kuriyan,
J. 		1997 EMBO J. 16 6141 9321393
1X45 Solution structure of the first PDZ domain
of amyloid beta A4 precursor protein-binding
family A, member 1 		Qin, X.R., Hayashi, F., Yokoyama, S. n/a to be published n/a n/a n/a
1Y7N Solution structure of the second PDZ domain
of the neuronal adaptor X11alpha and its
interaction with the C-terminal peptide
of the human copper chaperone for superoxide
dismutase 		Duquesne, A.E., de Ruijter, M., Brouwer,
J., Drijfhout, J.W., Nabuurs, S.B., Spronk,
C.A.E.M., Vuister, G.W., Ubbink, M., Canters,
G.W. 		2005 J.Biomol.Nmr 32 209 16132821
1YOV Insights into the Ubiquitin Transfer Cascade
from the refined structure of the activating
enzyme for NEDD8 		Walden, H., Podgorski, M.S., Schulman, B.A. 2003 Nature 422 330 12646924
1ZJD Structural and Mutational Analyses of the
Molecular Interactions between the Catalytic
Domain of Factor XIa and the Kunitz Protease
Inhibitor Domain of Protease Nexin 2 		Navaneetham, D., Jin, L., Pandey, P., Strickler,
J.E., Babine, R.E., Abdel-Meguid, S.S.,
Walsh, P.N. 		2005 J.Biol.Chem. 280 36165 16085935
2BP4 Structural Changes of Region 1-16 of the
Alzheimer Disease Amyloid Beta-Peptide Upon
Zinc Binding and in Vitro Aging. 		Zirah, S., Kozin, S.A., Mazur, A.K., Blond,
A., Cheminant, M., Segalas-Milazzo, I.,
Debey, P., Rebuffat, S. 		2006 J.Biol.Chem. 281 2151 n/a
8PTI Crystal structure of a Y35G mutant of bovine
pancreatic trypsin inhibitor. 		Housset, D., Kim, K.S., Fuchs, J., Woodward,
C., Wlodawer, A. 		1991 J.Mol.Biol. 220 757 1714504

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