Molecola del Mese
di David S. Goodsell
Trad. di Mauro Tonellato
Fattore di Tessuto

Indice 2006

Structure ID    Authors First Page Journal Name Title Volume ID Publication Year Pubmed
1A21 Muller, Y.A., Kelley, R.F., de Vos, A.M. 1106 Protein Sci. Hinge bending within the cytokine receptor
superfamily revealed by the 2.4 A crystal
structure of the extracellular domain of
rabbit tissue factor. 		7 1998 9605315
1ADZ Burgering, M.J., Orbons, L.P., van der Doelen,
A., Mulders, J., Theunissen, H.J., Grootenhuis,
P.D., Bode, W., Huber, R., Stubbs, M.T. 		395 J.Mol.Biol. The second Kunitz domain of human tissue
factor pathway inhibitor: cloning, structure
determination and interaction with factor
Xa. 		269 1997 9199408
1AHW Huang, M., Syed, R., Stura, E.A., Stone,
M.J., Stefanko, R.S., Ruf, W., Edgington,
T.S., Wilson, I.A. 		873 J.Mol.Biol. The mechanism of an inhibitory antibody on
TF-initiated blood coagulation revealed
by the crystal structures of human tissue
factor, Fab 5G9 and TF.G9 complex. 		275 1998 9480775
1BF9 Muranyi, A., Finn, B.E., Gippert, G.P., Forsen,
S., Stenflo, J., Drakenberg, T. 		10605 Biochemistry Solution structure of the N-terminal EGF-like
domain from human factor VII. 		37 1998 9692950
1BOY Harlos, K., Martin, D.M., O'Brien, D.P.,
Jones, E.Y., Stuart, D.I., Polikarpov, I.,
Miller, A., Tuddenham, E.G., Boys, C.W. 		662 Nature Crystal structure of the extracellular region
of human tissue factor. 		370 1994 8065454
1CVW Kemball-Cook, G., Johnson, D.J., Tuddenham,
E.G., Harlos, K. 		213 J.Struct.Biol. Crystal structure of active site-inhibited
human coagulation factor VIIa (des-Gla). 		127 1999 10544046
1DAN Banner, D.W., D'Arcy, A., Chene, C., Winkler,
F.K., Guha, A., Konigsberg, W.H., Nemerson,
Y., Kirchhofer, D. 		41 Nature The crystal structure of the complex of blood
coagulation factor VIIa with soluble tissue
factor. 		380 1996 8598903
1DVA Dennis, M.S., Eigenbrot, C., Skelton, N.J.,
Ultsch, M.H., Santell, L., Dwyer, M.A.,
O'Connell, M.P., Lazarus, R.A. 		465 Nature Peptide exosite inhibitors of factor VIIa
as anticoagulants. 		404 2000 10761907
1FAK Zhang, E., St Charles, R., Tulinsky, A. 2089 J.Mol.Biol. Structure of extracellular tissue factor
complexed with factor VIIa inhibited with
a BPTI mutant. 		285 1999 9925787
1FGN Huang, M., Syed, R., Stura, E.A., Stone,
M.J., Stefanko, R.S., Ruf, W., Edgington,
T.S., Wilson, I.A. 		873 J.Mol.Biol. The mechanism of an inhibitory antibody on
TF-initiated blood coagulation revealed
by the crystal structures of human tissue
factor, Fab 5G9 and TF.G9 complex. 		275 1998 9480775
1H9H Kraetzner, R., Wentzel, A., Kolmar, H., Uson,
I. 		n/a To be Published Complex of Eeti-II Mutant with Porcine Trypsin n/a n/a n/a
1H9I Kraetzner, R., Wentzel, A., Kolmar, H., Uson,
I. 		n/a To be Published Complex of Eeti-II Mutant with Porcine Trypsin n/a n/a n/a
1IRH Mine, S., Yamazaki, T., Miyata, T., Hara,
S., Kato, H. 		78 Biochemistry Structural mechanism for heparin-binding
of the third Kunitz domain of human tissue
factor pathway inhibitor. 		41 2002 11772005
1J9C Huang, M., Ruf, W., Edgington, T.S., Wilson,
I.A. 		n/a To be Published Ligand Induced Conformational Transitions
of Tissue Factor. Crystal Structure of the
Tissue Factor:Factor VIIa Complex. 		n/a n/a n/a
1JBU Eigenbrot, C., Kirchhofer, D., Dennis, M.S.,
Santell, L., Lazarus, R.A., Stamos, J.,
Ultsch, M.H. 		627 Structure The factor VII zymogen structure reveals
reregistration of beta strands during activation. 		9 2001 11470437
1JPS Faelber, K., Kirchhofer, D., Presta, L.,
Kelley, R.F., Muller, Y.A. 		83 J.Mol.Biol. The 1.85 A resolution crystal structures
of tissue factor in complex with humanized
Fab D3h44 and of free humanized Fab D3h44:
revisiting the solvation of antigen combining
sites. 		313 2001 11601848
1JPT Faelber, K., Kirchhofer, D., Presta, L.,
Kelley, R.F., Muller, Y.A. 		83 J.Mol.Biol. The 1.85 A resolution crystal structures
of tissue factor in complex with humanized
Fab D3h44 and of free humanized Fab D3h44:
revisiting the solvation of antigen combining
sites. 		313 2001 11601848
1K6Q Faelber, K., Kelley, R.F., Kirchhofer, D.,
Muller, Y.A. 		n/a To be Published The crystal structure of murine Fab D3 at
2.4 A resolution in comparison with the
humanised Fab D3h44 (1.85A) provides structural
insight into the humanisation process of
the D3 anti-tissue factor antibody 		n/a n/a n/a
1MTS Stubbs, M.T., Huber, R., Bode, W. 103 FEBS Lett. Crystal structures of factor Xa specific
inhibitors in complex with trypsin: structural
grounds for inhibition of factor Xa and
selectivity against thrombin. 		375 1995 7498454
1MTU Stubbs, M.T., Huber, R., Bode, W. 103 FEBS Lett. Crystal structures of factor Xa specific
inhibitors in complex with trypsin: structural
grounds for inhibition of factor Xa and
selectivity against thrombin. 		375 1995 7498454
1MTV Stubbs, M.T., Huber, R., Bode, W. 103 FEBS Lett. Crystal structures of factor Xa specific
inhibitors in complex with trypsin: structural
grounds for inhibition of factor Xa and
selectivity against thrombin. 		375 1995 7498454
1MTW Stubbs, M.T., Huber, R., Bode, W. 103 FEBS Lett. Crystal structures of factor Xa specific
inhibitors in complex with trypsin: structural
grounds for inhibition of factor Xa and
selectivity against thrombin. 		375 1995 7498454
1O5D Katz, B.A., Luong, C., Ho, J.D., Somoza,
J.R., Gjerstad, E., Tang, J., Williams,
S.R., Verner, E., Mackman, R.L., Young,
W.B., Sprengeler, P.A., Chan, H., Mortara,
K., Janc, J.W., McGrath, M.E. 		527 J.Mol.Biol. Dissecting and designing inhibitor selectivity
determinants at the S1 site using an artificial
Ala190 protease (Ala190 uPA) 		344 2004 15522303
1PG7 Eigenbrot, C., Meng, Y.G., Krishnamurthy,
R., Lipari, M.T., Presta, L., Devaux, B.,
Wong, T., Moran, P., Bullens, S., Kirchhofer,
D. 		433 J.Mol.Biol. Structural insight into how an anti-idiotypic
antibody against D3H44 (anti-tissue factor
antibody) restores normal coagulation. 		331 2003 12888350
1TFH Huang, M., Syed, R., Stura, E.A., Stone,
M.J., Stefanko, R.S., Ruf, W., Edgington,
T.S., Wilson, I.A. 		873 J.Mol.Biol. The mechanism of an inhibitory antibody on
TF-initiated blood coagulation revealed
by the crystal structures of human tissue
factor, Fab 5G9 and TF.G9 complex. 		275 1998 9480775
1TFX Burgering, M.J., Orbons, L.P., van der Doelen,
A., Mulders, J., Theunissen, H.J., Grootenhuis,
P.D., Bode, W., Huber, R., Stubbs, M.T. 		395 J.Mol.Biol. The second Kunitz domain of human tissue
factor pathway inhibitor: cloning, structure
determination and interaction with factor
Xa. 		269 1997 9199408
1UJ3 Ohto, U., Mizutani, R., Nakamura, M., Adachi,
H., Satow, Y. 		105 J.SYNCHROTRON RADIA. Crystal structure of a humanized Fab fragment
of anti-tissue-factor antibody in complex
with tissue factor. 		11 2004 14646147
1W0Y Groebke-Zbinden, K., Banner, D.W., Ackermann,
J., D'Arcy, A., Kirchhofer, D., Ji, Y.-H.,
Tschopp, T.B., Wallbaum, S., Weber, L. 		817 Bioorg.Med.Chem.Lett. Design of Selective Phenylglycine Amide Tissue
Factor/Factor Viia Inhibitors 		15 2005 n/a
1W2K Groebke-Zbinden, K., Banner, D.W., Ackermann,
J., D'Arcy, A., Kirchhofer, D., Ji, Y.-H.,
Tschopp, T.B., Wallbaum, S., Weber, L. 		817 Bioorg.Med.Chem.Lett. Design of Selective Phenylglycine Amide Tissue
Factor/Factor Viia Inhibitors 		15 2005 n/a
1W7X Groebke-Zbinden, K., Obst-Sander, U., Hilpert,
K., Kuehne, H., Banner, D.W., Boehm, H.-J.,
Stahl, M., Ackermann, J., Alig, L., Weber,
L., Wessel, H.P., Riederer, M.A., Tschopp,
T.B., Lave, T. 		5344 Bioorg.Med.Chem.Lett. Selective and Orally Bioavailable Phenylglycine
Tissue Factor/Factor Viia Inhibitors 		15 2005 n/a
1W8B Groebke-Zbinden, K., Obst-Sander, U., Hilpert,
K., Kuehne, H., Banner, D.W., Boehm, H.-J.,
Stahl, M., Ackermann, J., Alig, L., Weber,
L., Wessel, H.P., Riederer, M.A., Tschopp,
T.B., Lave, T. 		5344 Bioorg.Med.Chem.Lett. Selective and Orally Bioavailable Phenylglycine
Tissue Factor/Factor Viia Inhibitors 		15 2005 n/a
1WQV Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-eda,
M., Yabuta, N., Koga, T., Hattori, K., Shiraishi,
T., Haramura, M., Kodama, H., Esaki, T.,
Sato, H., Watanabe, Y., Itoh, S., Ohta,
M., Kozono, T. 		1227 Biochem.Biophys.Res.
Commun. 		Crystal structure of human factor VIIa/tissue
factor in complex with peptide mimetic inhibitor 		324 2004 15504346
1WSS Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-eda,
M., Yabuta, N., Koga, T., Hattori, K., Shiraishi,
T., Haramura, M., Kodama, H., Ono, Y., Esaki,
T., Sato, H., Watanabe, Y., Itoh, S., Ohta,
M., Kozono, T. 		n/a ACTA CRYSTALLOGR.,SECT.F Structure of human factor VIIa/tissue factor
in complex with a peptide-mimetic inhibitor:
high selectivity against thrombin by introducing
two charged groups in P2 and P4 		61 2005 n/a
1WTG Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-Eda,
M., Yabuta, N., Yoshihashi, K., Kitazawa,
T., Suzuki, T., Koga, T., Hattori, K., Shiraishi,
T., Haramura, M., Kodama, H., Ono, Y., Esaki,
T., Sato, H., Watanabe, Y., Itoh, S., Ohta,
M., Kozono, T. 		859 Biochem.Biophys.Res.
Commun. 		Novel interactions of large P3 moiety and
small P4 moiety in the binding of the peptide
mimetic factor VIIa inhibitor 		326 2005 15607748
1WUN Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-eda,
M., Yabuta, N., Yoshihashi, K., Kitazawa,
T., Suzuki, T., Koga, T., Hattori, K., Shiraishi,
T., Haramura, M., Kodama, H., Ono, Y., Esaki,
T., Sato, H., Watanabe, Y., Itoh, S., Ohta,
M., Kozono, T. 		589 Biochem.Biophys.Res.
Commun. 		Structure-based design of P3 moieties in
the peptide mimetic factor VIIa inhibitor 		327 2005 15629154
1WV7 Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-eda,
M., Yabuta, N., Yoshihashi, K., Kitazawa,
T., Suzuki, T., Koga, T., Hattori, K., Shiraishi,
T., Haramura, M., Kodama, H., Ono, Y., Esaki,
T., Sato, H., Watanabe, Y., Itoh, S., Ohta,
M., Kozono, T. 		589 Biochem.Biophys.Res.
Commun. 		Structure-based design of P3 moieties in
the peptide mimetic factor VIIa inhibitor 		327 2005 15629154
1YGC Olivero, A.G., Eigenbrot, C., Goldsmith,
R., Robarge, K., Artis, D.R., Flygare, J.,
Rawson, T., Sutherlin, D.P., Kadkhodayan,
S., Beresini, M., Elliott, L.O., DeGuzman,
G.G., Banner, D.W., Ultsch, M., Marzec,
U., Hanson, S.R., Refino, C., Bunting, S.,
Kirchhofer, D. 		9160 J.Biol.Chem. A selective, slow binding inhibitor of factor
VIIa binds to a nonstandard active site
conformation and attenuates thrombus formation
in vivo. 		280 2005 15632123
1Z6J Schweitzer, B.A., Neumann, W.L., Rahman,
H.K., Kusturin, C.L., Sample, K.R., Poda,
G.I., Kurumbail, R.G., Stevens, A.M., Stegeman,
R.A., Stallings, W.C., South, M.S. 		3006 Bioorg.Med.Chem.Lett. Structure-based design and synthesis of pyrazinones
containing novel P(1) 'side pocket' moieties
as inhibitors of TF/VIIa. 		15 2005 15913999
1ZR0 Schmidt, A.E., Chand, H.S., Cascio, D., Kisiel,
W., Bajaj, S.P. 		27832 J.Biol.Chem. Crystal structure of Kunitz domain 1 (KD1)
of tissue factor pathway inhibitor-2 in
complex with trypsin. Implications for KD1
specificity of inhibition 		280 2005 15932872
2B7D Young, W.B., Mordenti, J., Torkelson, S.,
Shrader, W.D., Kolesnikov, A., Rai, R.,
Liu, L., Hu, H., Leahy, E.M., Green, M.J.,
Sprengeler, P.A., Katz, B.A., Yu, C., Janc,
J.W., Elrod, K.C., Marzec, U.M., Hanson,
S.R. 		n/a Bioorg.Med.Chem.Lett. Factor VIIa inhibitors: Chemical optimization,
preclinical pharmacokinetics, pharmacodynamics,
and efficacy in an arterial baboon thrombosis
model. 		n/a 2006 16412633
2BOK Scharer, K., Morgenthaler, M., Paulini, R.,
Obst-Sander, U., Banner, D.W., Schlatter,
D., Benz, J., Stihle, M., Diederich, F. 		4400 Angew.Chem., Int.Ed.Engl. Quantification of Cation-Pi Interactions
in Protein-Ligand Complexes: Crystal-Structure
Analysis of Factor Xa Bound to a Quaternary
Ammonium Ion Ligand 		44 2005 n/a
2HFT Muller, Y.A., Ultsch, M.H., de Vos, A.M. 144 J.Mol.Biol. The crystal structure of the extracellular
domain of human tissue factor refined to
1.7 A resolution. 		256 1996 8609606

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