Molecola del Mese
di David S. Goodsell
Trad. di Mauro Tonellato
Caspasi

Indice 2004

PDB ID Authors First Page PubMed ID Journal Name Citation Title Volume No Publication Year
1BMQ Y.Okamoto, H.Anan, E.Nakai, K.Morihira, Y.Yonetoku, H.Kurihara, H.Sakashita, Y.Terai, M.Takeuchi, T.Shibanuma, Y.Isomura 11 9987822 Chem.Pharm.Bull. Peptide Base Interleukin-1Beta Converting Enzyme (Ice) Inhibitors : Synthesis, Structure Activity Relationship and Crystallographic Study of Ice-Inhibitor Complex 47 1999
1C15 P.Zhou, J.Chou, R.S.Olea, J.Yuan, G.Wagner 11265 10500165 Proc.Nat.Acad.Sci.USA Solution Structure of Apaf-1 Card and its Interaction with Caspase-9 Card: A Structural Basis for Specific Adaptor/Caspase Interaction 96 1999
1C9F K.Uegaki, T.Otomo, H.Sakahira, M.Shimizu, N.Yumoto, Y.Kyogoku, S.Nagata, T.Yamazaki 1121 10764577 J.Mol.Biol. Structure of the Cad Domain of Caspase-Activated DNase and Interaction with the Cad Domain of its Inhibitor 297 2000
1CVR A.Eichinger, H.-G.Beisel, U.Jacob, R.Huber, F.J.Medrano, A.Banbula, J.Potempa, J.Travis, W.Bode 5453 10523290 Embo J. Crystal Structure of Gingipain R: An Arg-Specific Bacterial Cysteine Proteinase with a Caspase-Like Fold 18 1999
1CWW C.L.Day, C.Dupont, M.Lackmann, D.L.Vaux, M.G.Hinds 1125 10578182 Cell Death Differ. Solution Structure and Mutagenesis of the Caspase Recruitment Domain (Card) from Apaf-1 6 1999
1CY5 D.E.Vaughn, J.Rodriguez, Y.Lazebnik, L.Joshua-Tor 439 10543941 J.Mol.Biol. Crystal Structure of the Apaf-1 Caspase Recruitment Domain: An Alpha-Helical Greek Key Fold for Apoptotic Signaling 293 1999
1F0C M.Renatus, Q.Zhou, H.R.Stennicke, S.J.Snipas, D.Turk, L.A.Bankston, R.C.Liddington, G.S.Salvesen 789 10903953 Structure Fold Des. Crystal Structure of the Apoptotic Suppressor Crma in its Cleaved Form 8 2000
1F2R T.Otomo, H.Sakahira, K.Uegaki, S.Nagata, T.Yamazaki 658 10932250 Nat.Struct.Biol. Structure of the Heterodimeric Complex between Cad Domains of Cad and Icad 7 2000
1FEW J.Chai, C.Du, J.W.Wu, S.Kyin, X.Wang, Y.Shi 855 10972280 Nature Structural and Biochemical Basis of Apoptotic Activation by Smac/Diablo 406 2000
1FQ3 E.Estebanez-Perpina, P.Fuentes-Prior, D.Belorgey, M.Braun, R.Kiefersauer, K.Maskos, R.Huber, H.Rubin, W.Bode 1203 11209755 Biol.Chem. Crystal Structure of the Caspase Activator Human Granzyme B, a Proteinase Highly Specific for an Asp-P1 Residue 381 2000
1G3F Z.Liu, C.Sun, E.T.Olejniczak, R.P.Meadows, S.F.Betz, T.Oost, J.Herrmann, J.C.Wu, S.W.Fesik 1004 11140637 Nature Structural Basis for Binding of Smac/Diablo to the Xiap Bir3 Domain. 408 2000
1GFW D.Lee, G.Chan, K.S.Vaidya, T.A.Francis, D.P.Nadeau, M.W.Lark, M.Gowen, K.Kikly, J.D.Winkler, C.-M.Sung, S.A.Long, J.L.Adams, C.Debouck, S.Richardson, M.A.Levy, W.E.Dewolf, Jr., P.M.Keller, T.Tomaszek, M.S.Head, M.D.Ryan, R.C.Haltiwanger, P.- H.Liang, C.A.Janson, P.J.Mcdevi 16007 n/a J.Biol.Chem. Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 which Inhibit Apoptosis and Maintain Cell Functionality 275 2000
1I3O S.J.Riedl, M.Renatus, R.Schwarzenbacher, Q.Zhou, C.Sun, S.W.Fesik, R.C.Liddington, G.S.Salvesen 791 11257232 Cell (Cambridge,Mass.) Structural Basis for the Inhibition of Caspase 3 by Xiap 104 2001
1I3P W.P.Dela Cruz, P.D.Friesen, A.J.Fisher 32933 11402050 J.Biol.Chem. Crystal Structure of Baculovirus P35 Reveals a Novel Conformational Change in the Reactive Site Loop After Caspase Cleavage 276 2001
1I3S W.P.Dela Cruz, P.D.Friesen, A.J.Fisher 32933 11402050 J.Biol.Chem. Crystal Structure of Baculovirus P35 Reveals a Novel Conformational Change in the Reactive Site Loop After Caspase Cleavage 276 2001
1I4O Y.Huang, Y.C.Park, R.L.Rich, D.Segal, D.G.Myszka, H.Wu 781 11257231 Cell (Cambridge,Mass.) Structural Basis of Caspase Inhibition by Xiap: Differential Roles of the Linker Versus the Bir Domain 104 2001
1I51 J.Chai, E.Shiozaki, S.M.Srinivasula, Q.Wu, P.Dataa, E.S.Alnemri, Y.Shi 769 11257230 Cell (Cambridge,Mass.) Structural Basis of Caspase-7 Inhibition by Xiap 104 2001
1IBX P.Zhou, A.A.Lugovskoy, J.S.Mccarty, P.Li, G.Wagner 6051 11371636 Proc.Nat.Acad.Sci.USA Solution Structure of Dff40 and Dff45 N-Terminal Domain Complex and Mutual Chaperone Activity of Dff40 and Dff45 98 2001
1JD4 J.W.Wu, A.E.Cocina, J.Chai, B.A.Hay, Y.Shi 95 11511363 Mol. Cell Structural Analysis of a Functional Diap1 Fragment Bound to Grim and Hid Peptides 8 2001
1JD5 J.W.Wu, A.E.Cocina, J.Chai, B.A.Hay, Y.Shi 95 11511363 Mol. Cell Structural Analysis of a Functional Diap1 Fragment Bound to Grim and Hid Peptides 8 2001
1JD6 J.W.Wu, A.E.Cocina, J.Chai, B.A.Hay, Y.Shi 95 11511363 Mol. Cell Structural Analysis of a Functional Diap1 Fragment Bound to Grim and Hid Peptides 8 2001
1JXQ M.Renatus, H.R.Stennicke, F.L.Scott, R.C.Liddington, G.S.Salvesen 14250 11734640 Proc.Nat.Acad.Sci.USA Dimer Formation Drives the Activation of the Cell Death Protease Caspase 9. 98 2001
1K86 J.Chai, Q.Wu, E.Shiozaki, S.M.Srinivasula, E.S.Alnemri, Y.Shi 299 11701129 Cell (Cambridge,Mass.) Crystal Structure of a Procaspase-7 Zymogen: Mechanisms of Activation and Substrate Binding 107 2001
1KMC S.J.Riedl, G.S.Salvesen, W.Bode n/a n/a To be Published Crystal Structure of the Caspase-7 / Xiap-Bir2 Complex n/a n/a
1LCY W.Li, S.M.Srinivasula, J.Chai, P.Li, J.W.Wu, Z.Zhang, E.S.Alnemri, Y.Shi 436 11967569 Nat.Struct.Biol. Structural Insights Into the Pro-Apoptotic Function of Mitochondrial Serine Protease Htra2/Omi 9 2002
1M72 C.M.Forsyth, D.Lemongello, D.J.Lacount, P.D.Friesen, A.J.Fisher 7001 n/a J.Biol.Chem. Crystal Structure of an Invertebrate Caspase 279 2004
1NW9 E.N.Shiozaki, J.Chai, D.J.Rigotti, S.J.Riedl, P.Li, S.M.Srinivasula, E.S.Alnemri, R.Fairman, Y.Shi 519 12620238 Mol.Cell Mechanism of Xiap-Mediated Inhibition of Caspase-9 11 2003
1P35 A.J.Fisher, W.d.Cruz, S.J.Zoog, C.L.Schneider, P.D.Friesen 2031 10205157 EMBO J Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition. 18 1999
1PN5 S.Hiller, A.Kohl, F.Fiorito, T.Herrmann, G.Wider, J.Tschopp, M.G.Grutter, K.Wuthrich 1199 14527388 Structure NMR Structure of the Apoptosis- and Inflammation-Related Nalp1 Pyrin Domain 11 2003
1PYO A.Schweizer, C.Briand, M.G.Grutter 42441 12920126 J.Biol.Chem. Crystal Structure of Caspase-2, Apical Initiator of the Intrinsic Apoptotic Pathway. 278 2003
1Q4Q J.Chai, N.Yan, J.R.Huh, J.-W.Wu, W.Li, B.A.Hay, Y.Shi 892 14517550 Nat.Struct.Biol. Molecular Mechanism of Reaper-Grim-Hid-Mediated Suppression of Diap1-Dependent Dronc Ubiquitination 10 2003
1QTN W.Watt, K.A.Koeplinger, A.M.Mildner, R.L.Heinrikson, A.G.Tomasselli, K.D.Watenpaugh 1135 10508785 Structure (London) The Atomic-Resolution Structure of Human Caspase-8, a Key Activator of Apoptosis 7 1999
1SDZ N.Yan, J.W.Wu, J.Chai, W.Li, Y.Shi 420 n/a Nat.Struct.Mol.Biol. Molecular Mechanisms of Drice Inhibition by Diap1 and Removal of Inhibition by Reaper, Hid, and Grim 11 2004
1SE0 N.Yan, J.W.Wu, J.Chai, Li W., Y.Shi 420 n/a Nat.Struct.Mol.Biol. Molecular Mechanisms of Drice Inhibition by Diap1 and Removal of Inhibition by Reaper, Hid, and Grim 11 2004
1V0D E.-J.Woo, Y.-G.Kim, M.-S.Kim, W.-D.Han, S.Shin, H.Robinson, S.-Y.Park, B.-H.Oh 531 n/a Molecular Cell Structural Mechanism for Inactivation and Activation of Cad/Dff40 in the Apoptotic Pathway 14 2004
2YGS H.Qin, S.Srinivasula, G.Wu, T.Fernandes-Alnemri, E.Alnemri, Y.Shi 549 10376594 Nature Structural Basis of Procaspase-9 Recruitment by Apoptotic Protease Activating Factor 1 399 1999
3CRD J.J.Chou, H.Matsuo, H.Duan, G.Wagner 171 9695946 Cell Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. 94 1998
3YGS H.Qin, S.Srinivasula, G.Wu, T.Fernandes-Alnemri, E.Alnemri, Y.Shi 549 10376594 Nature Structural Basis of Procaspase-9 Recruitment by Apoptotic Protease-Activating Factor 1 399 1999

 

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