Molecola del Mese
di David S. Goodsell
Trad. di Mauro Tonellato
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Molecola del Mese di David S. Goodsell Trad. di Mauro Tonellato |
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| PDB ID | Authors | First Page | PubMed ID | Journal Name | Citation Title | Volume No | Publication Year |
| 1ACJ | M.Harel, I.Schalk, L.Ehret-Sabatier, F.Bouet, M.Goeldner, C.Hirth, P.H.Axelsen, I.Silman, J.L.Sussman | 9031 | 8415649 | Proc Natl Acad Sci U S A | Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. | 90 | 1993 |
| 1ACL | M.Harel, I.Schalk, L.Ehret-Sabatier, F.Bouet, M.Goeldner, C.Hirth, P.H.Axelsen, I.Silman, J.L.Sussman | 9031 | 8415649 | Proc Natl Acad Sci U S A | Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. | 90 | 1993 |
| 1AMN | M.Harel, D.M.Quinn, H.K.Nair, I.Silman, J.L.Sussman | 2340 | n/a | J Am Chem Soc | The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase. | 118 | 1996 |
| 1AX9 | R.B.Ravelli, M.L.Raves, Z.Ren, D.Bourgeois, M.Roth, J.Kroon, I.Silman, J.L.Sussman | 1359 | 10089512 | Acta Crystallogr D Biol Crystallogr | Static Laue diffraction studies on acetylcholinesterase. | 54 | 1998 |
| 1B41 | G.Kryger, M.Harel, K.Giles, L.Toker, B.Velan, A.Lazar, C.Kronman, D.Barak, N.Ariel, A.Shafferman, I.Silman, J.L.Sussman | 1385 | 11053835 | Acta Crystallogr., Sect.D | Structures of Recombinant Native and E202Q Mutant Human Acetylcholinesterase Complexed with the Snake-Venom Toxin Fasciculin-II | 56 | 2000 |
| 1C2B | Y.Bourne, J.Grassi, P.E.Bougis, P.Marchot | 30370 | 10521413 | J.Biol.Chem. | Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X- Ray Crystallography | 274 | 1999 |
| 1C2O | Y.Bourne, J.Grassi, P.E.Bougis, P.Marchot | 30370 | 10521413 | J.Biol.Chem. | Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X- Ray Crystallography | 274 | 1999 |
| 1CFJ | C.B.Millard, G.Kryger, A.Ordentlich, H.M.Greenblatt, M.Harel, M.L.Raves, Y.Segall, D.Barak, A.Shafferman, I.Silman, J.L.Sussman | 7032 | 10353814 | Biochemistry | Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level. | 38 | 1999 |
| 1DX4 | M.Harel, G.Kryger, T.L.Rosenberry, W.D.Mallender, T.Lewis, R.J.Fletcher, J.M.Guss, I.Silman, J.L.Sussman | 1063 | 10892800 | Protein Sci. | Three-Dimensional Structures of Drosophila Melanogaster Acetylcholinesterase and of its Complexes with Two Potent Inhibitors | 9 | 2000 |
| 1DX6 | H.M.Greenblatt, G.Kryger, T.Lewis, I.Silman, J.L.Sussman | 321 | 10606746 | FEBS Lett. | Structure of Acetylcholinesterase Complexed with (-)-Galanthamine at 2.3A Resolution | 463 | 1999 |
| 1E3Q | C.E.Felder, M.Harel, I.Silman, J.L.Sussman | 1765 | 12351819 | Acta Crystallogr.,Sect.D | Structure of a Complex of the Potent and Specific Inhibitor Bw284C51 with Torpedo Californica Acetylcholinesterase | 58 | 2002 |
| 1E66 | H.Dvir, D.M.Wong, M.Harel, X.Barril, M.Orozco, F.J.Luque D.Munoz-Torrero, P.Camps, T.L.Rosenberry, I.Silman, J.L.Sussman | 2970 | 11863435 | Biochemistry | 3D Structure of Torpedo Californica Acetylcholinesterase Complexed with Huprine X at 2.1 A Resolution | 41 | 2002 |
| 1EA5 | M.Harel, M.Weik, I.Silman, J.L.Sussman | n/a | n/a | To be Published | Native Acetylcholinesterase (E.C. 3.1.1.7) From Torpedo Californica at 1.8A Resolution | n/a | n/a |
| 1EEA | M.L.Raves, K.Giles, J.D.Schrag, M.F.Schmid, G.N.Phillips, C.Wah, A.J.Howard, I.Silman, J.L.Sussman | n/a | n/a | Structure and Function of Cholinesterases and Related Proteins | Quaternary Structure of Tetrameric Acetylcholinesterase | n/a | 1998 |
| 1EVE | G.Kryger, I.Silman, J.L.Sussman | 297 | 10368299 | Structure Fold Des | Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. | 7 | 1999 |
| 1F8U | G.Kryger, M.Harel, M.Harel, A.Shafferman, I.Silman, J.L.Sussman | 1385 | 11053835 | Acta Crystallogr., Sect.D | Structures of Recombinant Native and E202Q Mutant Human Acetylcholinesterase Complexed with the Snake-Venom Toxin Fasciculin-II | 56 | 2000 |
| 1FAS | M.H.le Du, P.Marchot, P.E.Bougis, J.C.Fontecilla-Camps | 22122 | 1429564 | J Biol Chem | 1.9-A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom. | 267 | 1992 |
| 1FSC | M.H.LeDu, D.Housset, P.Marchot, P.E.Bougis, J.Navaza, C.FontecillaCamps | 87 | n/a | Acta Crystallogr D Biol Crystallogr | Structure of fasciculin 2 from green mamba snake venom: Evidence for unusual loop flexibility. | 52 | 1996 |
| 1FSS | M.Harel, G.J.Kleywegt, R.B.Ravelli, I.Silman, J.L.Sussman | 1355 | 8747462 | Structure | Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. | 3 | 1995 |
| 1GPK | H.Dvir, H.L.Jiang, D.M.Wong, M.Harel, M.Chetrit, X.C.He, G.Y.Jin, G.L.Yu, X.C.Tang, I.Silman, D.L.Bai, J.L.Sussman | 10810 | 12196020 | Biochemistry | X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement | 41 | 2002 |
| 1GPN | H.Dvir, H.L.Jiang, D.M.Wong, M.Harel, M.Chetrit, X.C.He, G.Y.Jin, G.L.Yu, X.C.Tang, I.Silman, D.L.Bai, J.L.Sussman | 10810 | 12196020 | Biochemistry | X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement | 41 | 2002 |
| 1GQR | P.Bar-on, C.B.Millard, M.Harel, H.Dvir, A.Enz, J.L.Sussman, I.Silman | 3555 | 11888271 | Biochemistry | Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine | 41 | 2002 |
| 1GQS | P.Bar-on, C.B.Millard, M.Harel, H.Dvir, A.Enz, J.L.Sussman, I.Silman | 3555 | 11888271 | Biochemistry | Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine | 41 | 2002 |
| 1H22 | D.M.Wong, H.M.Greenblatt, H.Dvir, P.R.Carlier, Y.Han, Y.Pang, I.Silman, J.L.Sussman | 363 | n/a | J.Am.Chem.Soc. | Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity | 125 | 2003 |
| 1H23 | D.M.Wong, H.M.Greenblatt, H.Dvir, P.R.Carlier, Y.Han, Y.Pang, I.Silman, J.L.Sussman | 363 | n/a | J.Am.Chem.Soc. | Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity | 125 | 2003 |
| 1HBJ | C.Doucet-Personeni, P.D.Bentley, R.J.Fletcher, A.Kinkaid, G.Kryger, B.Pirard, A.Taylor, R.Taylor, J.Taylor, R.Viner, I.Silman, J.L.Sussman, H.M.Greenblatt, T.Lewis | 3203 | 11563919 | J.Med.Chem. | A Structure-Based Design Approach to the Development of Novel, Reversible Ache Inhibitors | 44 | 2001 |
| 1J06 | Y.Bourne, P.Taylor, Z.Radic, P.Marchot | 1 | 12505979 | Embo J. | Structural Insights Into Ligand Interactions at the Acetylcholinesterase Peripheral Anionic Site | 22 | 2003 |
| 1J07 | Y.Bourne, P.Taylor, Z.Radic, P.Marchot | 1 | 12505979 | Embo J. | Structural Insights Into Ligand Interactions at the Acetylcholinesterase Peripheral Anionic Site | 22 | 2003 |
| 1JJB | G.Koellner, T.Steiner, C.B.Millard, I.Silman, J.L.Sussman | 721 | 12095250 | J.Mol.Biol. | A Neutral Molecule in a Cation-Binding Site: Specific Binding of a Peg-Sh to Acetylcholinesterase from Torpedo Californica | 320 | 2002 |
| 1JMY | S.A.Moore, R.L.Kingston, K.M.Loomes, O.Hernell, L.Blackberg, H.M.Baker, E.N.Baker | 511 | 11563913 | J.Mol.Biol. | The Structure of Truncated Recombinant Human Bile Salt-Stimulated Lipase Reveals Bile Salt-Independent Conformational Flexibility at the Active-Site Loop and Provides Insights Into Heparin Binding | 312 | 2001 |
| 1KU6 | Y.Bourne, W.Burmeister, P.Taylor, P.Marchot | n/a | n/a | To be Published | Acetylcholinesterase Inhibition by Fasciculin Revisited | n/a | n/a |
| 1MAA | Y.Bourne, P.Taylor, P.E.Bougis, P.Marchot | 2963 | 9915834 | J Biol Chem | Crystal structure of mouse acetylcholinesterase. A peripheral site- occluding loop in a tetrameric assembly. | 274 | 1999 |
| 1MAH | Y.Bourne, P.Taylor, P.Marchot | 503 | 8521480 | Cell | Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex. | 83 | 1995 |
| 1N5M | Y.Bourne, P.Taylor, Z.Radic, P.Marchot | 1 | 12505979 | Embo J. | Structural Insights Into Ligand Interactions at the Acetylcholinesterase Peripheral Anionic Site | 22 | 2003 |
| 1N5R | Y.Bourne, P.Taylor, Z.Radic, P.Marchot | 1 | 12505979 | Embo J. | Structural Insights Into Ligand Interactions at the Acetylcholinesterase Peripheral Anionic Site | 22 | 2003 |
| 1OCE | C.Bartolucci, E.Perola, L.Cellai, M.Brufani, D.Lamba | 5714 | 10231521 | Biochemistry | "Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase. | 38 | 1999 |
| 1Q83 | Y.Bourne, H.C.Kolb, Z.Radic, K.B.Sharpless, P.Taylor, P.Marchot | 1449 | n/a | Proc.Nat.Acad.Sci.USA | Freeze-Frame Inhibitor Captures Acetylcholinesterase in a Unique Conformation | 101 | 2004 |
| 1Q84 | Y.Bourne, H.C.Kolb, Z.Radic, K.B.Sharpless, P.Taylor, P.Marchot | 1449 | n/a | Proc.Nat.Acad.Sci.USA | Freeze-Frame Inhibitor Captures Acetylcholinesterase in a Unique Conformation | 101 | 2004 |
| 1QID | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QIE | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QIF | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QIG | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QIH | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QII | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QIJ | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QIK | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QIM | M.Weik, R.B.G.Ravelli, G.Kryger, S.Mcsweeney, M.L.Raves, M.Harel, P.Gros, I.Silman, J.Kroon, J.L.Sussman | 623 | 10639129 | Proc.Nat.Acad.Sci.USA | Specific Chemical and Structural Damage to Proteins by Synchrotron Radiation | 97 | 2000 |
| 1QM7 | M.H.Le Du, A.Ricciardi, M.Khayati, R.Menez, J.C.Boulain, A.Menez, F.Ducancel | 1017 | 10686100 | J.Mol.Biol. | Stability of a Structural Scaffold Upon Activity Transfer : X-Ray Structure of a Three Fingers Chimeric Protein. | 296 | 2000 |
| 1QO9 | M.Harel, G.Kryger, T.L.Rosenberry, W.D.Mallender, T.Lewis, R.J.Fletcher, J.M.Guss, I.Silman, J.L.Sussman | 1063 | 10892800 | Protein Sci. | Three-Dimensional Structures of Drosophila Melanogaster Acetylcholinesterase and of its Complexes with Two Potent Inhibitors | 9 | 2000 |
| 1QON | M.Harel, G.Kryger, T.L.Rosenberry, W.D.Mallender, T.Lewis, R.J.Fletcher, J.M.Guss, I.Silman, J.L.Sussman | 1063 | 10892800 | Protein Sci. | Three-Dimensional Structures of Drosophila Melanogaster Acetylcholinesterase and of its Complexes with Two Potent Inhibitors | 9 | 2000 |
| 1QTI | C.Bartolucci, E.Perola, C.Pilger, G.Fels, D.Lamba | 182 | 11119642 | To be Published | Three-Dimensional Structure of a Complex of Galanthamine (Nivalin (R)) with Acetylcholinesterase from Torpedo Californica: Implications for the Design of New Anti-Alzheimer Drugs | 42 | 2001 |
| 1SOM | C.B.Millard, G.Kryger, A.Ordentlich, H.M.Greenblatt, M.Harel, M.L.Raves, Y.Segall, D.Barak, A.Shafferman, I.Silman, J.L.Sussman | 7032 | 10353814 | Biochemistry | Crystal Structures of Aged Phosphonylated Acetylcholinesterase: Nerve Agent Reaction Products at the Atomic Level | 38 | 1999 |
| 1VOT | M.L.Raves, M.Harel, Y.P.Pang, I.Silman, A.P.Kozikowski, J.L.Sussman | 57 | 8989325 | Nat Struct Biol | Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. | 4 | 1997 |
| 1VXO | C.B.Millard, G.Koellner, A.Ordentlich, A.Shafferman, I.Silman, J.L.Sussman | 9883 | n/a | J.Am.Chem.Soc. | Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad | 121 | 1999 |
| 1VXR | C.B.Millard, G.Koellner, A.Ordentlich, A.Shafferman, I.Silman, J.L.Sussman | 9883 | n/a | J.Am.Chem.Soc. | Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad | 121 | 1999 |
| 2ACE | M.L.Raves, M.Harel, Y.-P.Pang, I.Silman, A.P.Kozikowski, J.L.Sussman | n/a | 8989325 | To be Published | 3D Structure of Acetylcholinesterase Complexed with the Nootropic Alkaloid, (-)-Huperzine A | n/a | n/a |
| 2ACK | R.B.Ravelli, M.L.Raves, Z.Ren, D.Bourgeois, M.Roth, J.Kroon, I.Silman, J.L.Sussman | 1359 | 10089512 | Acta Crystallogr D Biol Crystallogr | Static Laue diffraction studies on acetylcholinesterase. | 54 | 1998 |
| 2DFP | C.B.Millard, G.Kryger, A.Ordentlicht, H.M.Greenblatt, M.Harel, M.L.Raves, Y.Segall, D.Barak, A.Shafferman, I.Silman, J.L.Sussman | 7032 | 10353814 | Biochemistry | Crystal Structures of Aged Phosphylated Acetylcholinesterase: Nerve Agent Reaction Products at the Atomic Level | 38 | 1999 |
Indietro: Esplorando la Struttura
