Molecola del Mese
di David S. Goodsell
Trad. di Mauro Tonellato
Serpina
Indice 2004

PianetaChimica

PDB ID Authors First Page PubMed ID Journal Name Citation Title Volume No Publication Year
1A7C Y.Xue, P.Bjorquist, T.Inghardt, M.Linschoten, D.Musil, L.Sjolin, J.Deinum 627 9634700 Structure Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide. 6 1998
1ANT R.W.Carrell, P.E.Stein, G.Fermi, M.R.Wardell 257 8087553 Structure Biological implications of a 3 A structure of dimeric antithrombin [see comments] 2 1994
1AS4 C.M.Lukacs, H.Rubin, D.W.Christianson 3297 9521649 Biochemistry Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction. 37 1998
1ATH H.A.Schreuder, B.de Boer, R.Dijkema, J.Mulders, H.J.Theunissen, P.D.Grootenhuis, W.G.Hol 48 7656006 Nat Struct Biol The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions. 1 1994
1ATT L.Mourey, J.P.Samama, M.Delarue, M.Petitou, J.Choay, D.Moras 223 8331659 J Mol Biol Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution. 232 1993
1ATU S.E.Ryu, H.J.Choi, K.S.Kwon, K.N.Lee, M.H.Yu 1181 8939743 Structure The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved alpha1-antitrypsin at 2.7 A. 4 1996
1AZX L.Jin, J.P.Abrahams, R.Skinner, M.Petitou, R.N.Pike, R.W.Carrell 14683 9405673 Proc Natl Acad Sci U S A The anticoagulant activation of antithrombin by heparin. 94 1997
1B3K A.M.Sharp, P.E.Stein, N.S.Pannu, R.W.Carrell, M.B.Berkenpas, D.Ginsburg, D.A.Lawrence, R.J.Read 111 10368279 Structure (London) The Active Conformation of Plasminogen Activator Inhibitor 1, a Target for Drugs to Control Fibrinolysis and Cell Adhesion 7 1999
1BR8 R.Skinner, W.S.Chang, L.Jin, X.Pei, J.A.Huntington, J.P.Abrahams, R.W.Carrell, D.A.Lomas 9 9761669 J Mol Biol Implications for function and therapy of a 2.9 A structure of binary- complexed antithrombin. 283 1998
1BY7 S.J.Harrop, L.Jankova, M.Coles, D.Jardine, J.S.Whittaker, A.R.Gould, A.Meister, G.C.King, B.C.Mabbutt, P.M.G.Curmi 43 10368272 Structure Fold Des The Crystal Structure of Plasminogen Activator Inhibitor-2 at 2.0 A Resolution: Implications for Serpin Function 7 1999
1C5G H.M.Tucker, J.Mottenen, E.J.Goldsmith, R.D.Gerard 442 7664104 Nat.Struct.Biol. Engineering of Plasminogen Activator Inhibitor-1 to Reduce the Rate of Latency Transition 2 1995
1C8O M.Simonovic, P.G.W.Gettins, K.Volz 1423 10975564 Protein Sci. Crystal Structure of Viral Serpin Crma Provides Insights Into its Mechanism of Cysteine Proteinase Inhibition. 9 2000
1D5S M.A.Dunstone, W.Dai, J.C.Whisstock, J.Rossjohn, R.N.Pike, S.C.Feil, B.F.Le Bonniec, M.W.Parker, S.P.Bottomley 417 10716194 Protein Sci. Cleaved Antitrypsin Polymers at Atomic Resolution 9 2000
1DB2 H.Nar, M.Bauer, J.M.Stassen, D.Lang, A.Gils, P.J.Declerck 683 10731421 J.Mol.Biol. Plasminogen Activator Inhibitor 1. Structure of the Native Serpin, Comparison to its Other Conformers and Implications for Serpin Inactivation 297 2000
1DVM T.J.Stout, H.Graham, D.I.Buckley, D.J.Matthews 8460 10913251 Biochemistry Structures of Active and Latent Pai-1: A Possible Stabilizing Role for Chloride Ions 39 2000
1DVN T.J.Stout, H.Graham, D.I.Buckley, D.J.Matthews 8460 10913251 Biochemistry Structures of Active and Latent Pai-1: A Possible Stabilizing Role for Chloride Ions 39 2000
1DZG J.A.Huntington, A.J.Mccoy, K.J.Belzar, X.Y.Pei, P.G.W.Gettins, R.W.Carrell 15377 10809774 J.Biol.Chem. The Conformational Activation of Antithrombin-A 2.85 Angstrom Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge Region and Heparin Binding Regions 275 2000
1DZH J.A.Huntington, A.J.Mccoy, K.J.Belzar, X.Y.Pei, P.G.W.Gettins, R.W.Carrell 15377 10809774 J.Biol.Chem. The Conformational Activation of Antithrombin-A 2.85 Angstrom Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge Region and Heparin Binding Regions 275 2000
1E03 L.Jin, J.-P.Abrahams, R.Skinner, M.Petitou, R.N.Pike, R.W.Carrell 601 9405673 Proc.Nat.Acad.Sci.USA The Anticoagulant Activation of Antithrombin by Heparin 266 1997
1E04 R.Skinner, J.-P.Abrahams, J.C.Whisstock, A.M.Lesk, R.W.Carrell, M.Wardell 601 9067613 J.Mol.Biol. The 2.6A Structure of Antithrombin Indicates a Conformational Change at the Heparin Binding Site 266 1997
1E05 R.Skinner, J.-P.Abrahams, J.C.Whisstock, A.M.Lesk, R.W.Carrell, M.Wardell 601 9067613 J.Mol.Biol. The 2.6A Structure of Antithrombin Indicates a Conformational Change at the Heparin Binding Site 266 1997
1EB2 J.W.Liebeschuetz, S.D.Jones, P.J.Morgan, C.W.Murray, A.D.Rimmer, J.M.E.Roscoe, B.Waszkowycz, P.M.Welsh, W.A.Wylie, S.C.Young, H.Martin, J.Mahler, L.Brady' K.Wilkinson n/a n/a To be Published Pro_Select: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa Inhibitors n/a n/a
1EZX J.A.Huntington, R.J.Read, R.W.Carrell 923 11057674 Nature Structure of a Serpin-Protease Complex Shows Inhibition by Deformation 407 2000
1F0C M.Renatus, Q.Zhou, H.R.Stennicke, S.J.Snipas, D.Turk, L.A.Bankston, R.C.Liddington, G.S.Salvesen 789 10903953 Structure Fold Des. Crystal Structure of the Apoptotic Suppressor Crma in its Cleaved Form 8 2000
1HIA P.R.Mittl, S.Di Marco, G.Fendrich, G.Pohlig, J.Heim, C.Sommerhoff, H.Fritz, J.P.Priestle, M.G.Grutter 253 9032072 Structure A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex. 5 1997
1HJ9 H.-K.S.Leiros, S.M.Mcsweeney, A.O.Smalas 488 n/a Acta Crystallogr.,Sect.D Atomic Resolution Structure of Trypsin Provide Insight Into Structural Radiation Damage 57 2001
1HLE U.Baumann, W.Bode, R.Huber, J.Travis, J.Potempa 1207 1518052 J Mol Biol Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution. 226 1992
1HP7 S.-J.Kim, J.-R.Woo, E.J.Seo, M.-H.Yu, S.-E.Ryu 109 11178897 J.Mol.Biol. A 2.1 A Resolution Structure of an Uncleaved Alpha(1)-Antitrypsin Shows Variability of the Reactive Center and Other Loops. 306 2001
1IMV M.Simonovic, P.G.W.Gettins, K.Volz 11131 11562499 Proc.Nat.Acad.Sci.USA Crystal Structure of Human Pedf, a Potent Anti-Angiogenic and Neurite Growth-Promoting Factor 98 2001
1IZ2 H.Im, M.-S.Woo, K.Y.Hwang, M.-H.Yu 46347 12244055 J.Biol.Chem. Interactions Causing the Kinetic Trap in Serpin Protein Folding 277 2002
1JJO C.Briand, S.V.Kozlov, P.Sonderegger, M.G.Gruetter 18 11557034 FEBS Lett. Crystal Structure of Neuroserpin: A Neuronal Serpin Involved in a Conformational Disease. 505 2001
1JMJ T.P.Baglin, R.W.Carrell, F.C.Church, C.T.Esmon, J.A.Huntington 11079 12169660 Proc.Nat.Acad.Sci.USA Crystal Structures of Native and Thrombin-Complexed Heparin Cofactor II Reveal a Multistep Allosteric Mechanism 99 2002
1JMO T.P.Baglin, R.W.Carrell, F.C.Church, C.T.Esmon, J.A.Huntington 11079 12169660 Proc.Nat.Acad.Sci.USA Crystal Structures of Native and Thrombin-Complexed Heparin Cofactor II Reveal a Multistep Allosteric Mechanism 99 2002
1JRR L.Jankova, S.J.Harrop, D.N.Saunders, J.L.Andrews, K.C.Bertram, A.R.Gould, M.S.Baker, P.M.G.Curmi n/a 11546761 To be Published Crystal Structure of the Complex of Plasminogen Activator Inhibitor 2 with a Peptide Mimicking the Reactive Center Loop n/a n/a
1JTI M.Yamasaki, Y.Arii, B.Mikami, M.Hirose 113 11779232 J.Mol.Biol. Loop-Inserted and Thermostabilized Structure of P1-P1' Cleaved Ovalbumin Mutant R339T 315 2002
1JVQ A.Zhou, J.A.Huntington, D.A.Lomas, R.W.Carrell, P.E.Stein n/a n/a To be Published Serpin Structure Shows How Small Peptides Block and Reverse Polymerisation n/a n/a
1K9O S.Ye, A.L.Cech, R.Belmares, R.C.Bergstrom, Y.Tong, D.R.Corey, M.R.Kanost, E.J.Goldsmith 979 11685246 Nat.Struct.Biol. The Structure of a Michaelis Serpin-Protease Complex 8 2001
1KCT H.K.Song, K.N.Lee, K.S.Kwon, M.H.Yu, S.W.Suh 150 8543039 FEBS Lett Crystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loop. 377 1995
1LJ5 n/a n/a n/a Unpublished n/a n/a n/a
1LK6 A.Zhou, P.E.Stein, J.A.Huntington, R.W.Carrell 15116 12578831 J.Biol.Chem. Serpin Polymerization is Prevented by a Hydrogen Bond Network that is Centered on His-334 and Stabilized by Glycerol 278 2003
1LQ8 J.A.Huntington, M.Kjellberg, J.Stenflo 205 12575940 Structure Crystal Structure of Protein C Inhibitor Provides Insights Into Hormone Binding and Heparin Activation 11 2003
1M93 M.Simonovic, P.G.W.Gettins, K.Volz 1423 10975564 Protein Sci. Crystal Structure of Viral Serpin Crma Provides Insights Into its Mechanism of Cysteine Proteinase Inhibition 9 2000
1MTP J.A.Irving, L.D.Cabrita, J.Rossjohn, R.N.Pike, S.P.Bottomley, J.C.Whisstock 387 12679017 Structure The 1.5 Crystal Structure of a Prokaryote Serpin: Controlling Conformational Change in a Heated Environment 11 2003
1OC0 A.Zhou, J.Huntington, N.Pannu, R.Carrell, R.Read 541 n/a Nat.Struct.Biol. How Vitronectin Binds Pai-1 to Modulate Fibrinolysis and Cell Migration 10 2003
1OO8 A.Dementiev, M.Simonovic, K.Volz, P.G.Gettins 37881 12860985 J.Biol.Chem. Canonical Inhibitor-Like Interactions Explain Reactivity of Alpha1-Proteinase Inhibitor Pittsburgh and Antithrombin with Proteinases 278 2003
1OPH A.Dementiev, M.Simonovic, K.Volz, P.G.Gettins 37881 12860985 J.Biol.Chem. Canonical Inhibitor-Like Interactions Explain Reactivity of Alpha1-Proteinase Inhibitor Pittsburgh and Antithrombin with Proteinases 278 2003
1OVA P.E.Stein, A.G.Leslie, J.T.Finch, R.W.Carrell 941 1942038 J Mol Biol Crystal structure of uncleaved ovalbumin at 1.95 A resolution. 221 1991
1P4L J.Dam, R.Guan, K.Natarajan, N.Dimasi, L.K.Chlewicki, D.M.Kranz, P.Schuck, D.H.Margulies, R.A.Mariuzza 1213 14595439 Nat.Immunol. Variable Mhc Class I Engagement by Ly49 Natural Killer Cell Receptors Demonstrated by the Crystal Structure of Ly49C Bound to H-2K(B). 4 2003
1PSI P.R.Elliott, D.A.Lomas, R.W.Carrell, J.P.Abrahams 676 8756325 Nat Struct Biol Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. 3 1996
1QLP P.R.Elliott, X.Y.Pei, T.Dafforn, D.A.Lomas 1274 n/a Protein Sci. Topography of a 2.0 A Structure of Alpha1-Antitrypsin Reveals Targets for Rational Drug Design to Prevent Conformational Disease. 9 2000
1QMB J.A.Huntington, N.S.Pannu, B.Hazes, R.J.Read, D.A.Lomas, R.W.Carrell 449 10543942 J.Mol.Biol. A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease 293 1999
1QMN B.Gooptu, B.Hazes, W.-S.W.Chang, T.R.Dafforn, R.W.Carrell, R.J.Read, D.A.Lomas 67 10618372 Proc.Nat.Acad.Sci.USA Inactive Conformation of the Serpin Alpha1-Antichymotrypsin Indicates Two- Stage Insertion of the Reactive Loop: Implications for Inhibitory Function and Conformational Disease 97 2000
1SEK J.Li, Z.Wang, B.Canagarajah, H.Jiang, M.Kanost, E.J.Goldsmith 103 10368276 Structure Fold Des The structure of active serpin 1K from Manduca sexta. 7 1999
1UHG M.Yamasaki, N.Takahashi, M.Hirose 35524 12840013 J.Biol.Chem. Crystal Structure of S-Ovalbumin as a Non-Loop-Inserted Thermostabilized Serpin Form 278 2003
1UTN H.-K.S.Leiros, B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski, N.P.Willassen, A.O.Smalas 1056 n/a Protein Sci. Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements 13 2004
1UTO H.-K.S.Leiros, B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski, N.P.Willassen, A.O.Smalas 1056 n/a Protein Sci. Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements 13 2004
1UTP H.-K.S.Leiros, B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski, N.P.Willassen, A.O.Smalas 1056 n/a Protein Sci. Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements 13 2004
1UTQ H.-K.S.Leiros, B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski, N.P.Willassen, A.O.Smalas 1056 n/a Protein Sci. Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements 13 2004
1VAC D.H.Fremont, E.A.Stura, M.Matsumura, P.A.Peterson, I.A.Wilson 2479 7708669 Proc Natl Acad Sci U S A Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. 92 1995
2ACH U.Baumann, R.Huber, W.Bode, D.Grosse, M.Lesjak, C.B.Laurell 595 2016749 J Mol Biol Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins. 218 1991
2ANT R.Skinner, J.P.Abrahams, J.C.Whisstock, A.M.Lesk, R.W.Carrell, M.R.Wardell 601 9067613 J.Mol.Biol. The 2.6 A Structure of Antithrombin Indicates a Conformational Change at the Heparin Binding Site 266 1997
3CAA C.M.Lukacs, J.Q.Zhong, M.I.Plotnick, H.Rubin, B.S.Cooperman, D.W.Christianson 888 8836107 Nat Struct Biol Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement. 3 1996
4CAA C.M.Lukacs, J.Q.Zhong, M.I.Plotnick, H.Rubin, B.S.Cooperman, D.W.Christianson 888 8836107 Nat Struct Biol Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement. 3 1996
7API R.Engh, H.Lobermann, M.Schneider, G.Wiegand, R.Huber, C.B.Laurell 407 2785270 Protein Eng The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism. 2 1989
8API R.Engh, H.Lobermann, M.Schneider, G.Wiegand, R.Huber, C.B.Laurell 407 2785270 Protein Eng The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism. 2 1989
9API R.Engh, H.Lobermann, M.Schneider, G.Wiegand, R.Huber, C.B.Laurell 407 2785270 Protein Eng The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism. 2 1989
9PAI K.Aertgeerts, H.L.De Bondt, C.J.De Ranter, P.J.Declerck 891 7552714 Nat Struct Biol Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1. 2 1995

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